Heterogeneity of Colon Cancer Stem Cells
Heterogeneity of Colon Cancer Stem Cells
复制标题
DOI：
10.1007/978-3-030-14366-4_7
复制
发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Tomita, Hiroyuki
中科院分区：
文献类型：
--
作者：
Hirata, Akihiro;Hatano, Yuichiro;Tomita, Hiroyuki
结直肠癌（CRC）仍然是全球癌症死亡的第四大原因。癌症干细胞（CSCs）由于其在包括CRC在内的一系列癌症中的潜在临床意义而引起了极大的兴趣。CSC最初被认为是具有明确定义的表型和分子特征的细胞群。然而，越来越多的证据表明，CSC代表了一个表型和功能异质性群体。最近的研究还表明，结直肠CSC是动态的，而不是静态的群体，除了内在的细胞因素，如遗传和表观遗传改变，不断改变各种外在因素。因此，CSC不再代表固定的目标群体，它们的异质性和动态性质在建立特定的治疗策略方面存在严重问题。本章总结了过去和目前的文献相关的CSC群体异质性和CRC组织中的动态，包括不同的CSC亚群和信号通路的存在和肿瘤内和肿瘤外的因素参与调控的CSC在癌组织中的证据。
Colorectal cancer (CRC) remains the fourth leading cause of cancer death worldwide. Cancer stem cells (CSCs) have attracted a great deal of interest because of their potential clinical implications in a range of cancers, including CRC. CSCs were initially considered to be cell populations with well-defined phenotypic and molecular characteristics. However, accumulating evidence suggests that CSCs represent a phenotypically and functionally heterogeneous population. Recent studies also demonstrate colorectal CSCs to be dynamic rather than static populations that are continuously altered by various extrinsic factors in addition to intrinsic cellular factors such as genetic and epigenetic alterations. Thus, CSCs do not represent a fixed target population any longer, and their heterogeneous and dynamic nature present a serious problem in establishing specific therapeutic strategies. This chapter summarizes past and current literature related to CSC population heterogeneity and dynamics in CRC tissues, including evidence of the presence of distinct CSC subpopulations and signaling pathways and intra-and extra-tumoral factors involved in the regulation of CSCs in cancer tissues.