Tight junctions and tight junction proteins in mammalian epidermis
Tight junctions and tight junction proteins in mammalian epidermis
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DOI：
10.1016/j.ejpb.2008.08.007
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发表时间：
2009-06-01
影响因子：
4.9
通讯作者：
Brandner, Johanna M.
中科院分区：
文献类型：
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作者：
Brandner, Johanna M.
紧密连接(TJ)是一种形成屏障的细胞-细胞连接，存在于多种细胞类型和组织中，但在哺乳动物表皮中的存在是最近几年才被证明的。在哺乳动物的表皮中发现了多种TJ蛋白，包括Claudin家族的几个成员、occludin和JAM-A以及ZO-1和Mupp-1。TJ蛋白在表皮中表现出复杂的表达和定位模式。尽管如此，尽管在不同的层中发现了几种TJ蛋白，但典型的TJ结构仅在颗粒层中发现。TJ对皮肤的屏障功能很重要，特别是对内向外的屏障。此外，TJ蛋白可能还参与了表皮细胞的其他功能。在一些皮肤病中，如银屑病，TJ蛋白的定位和表达会发生改变。同时，从简单的上皮细胞中已知有几个TJ调节器。我们讨论了它们对药物进入皮肤和通过皮肤输送的推定可用性。(C)2008爱思唯尔B.V.保留所有权利。
Tight junctions (TJ) are barrier forming cell-cell junctions that are found in a variety of cell types and tissues but their existence in mammalian epidermis has been shown only in the last years. A variety of TJ proteins were identified in mammalian epidermis, comprising several members of the claudin family, occludin, and JAM-A as well as ZO-1 and MUPP-1. TJ proteins exhibit complex expression and localization patterns in the epidermis. Nonetheless, even though several TJ proteins are found in various layers, typical TJ structures are only found in the stratum granulosum. TJ are important for barrier function of the skin, especially for inside-out barrier. In addition, TJ proteins might also be involved in additional functions in epidermal cells. Localization and expression of TJ proteins are altered in several skin diseases, e.g. psoriasis. Meanwhile several TJ modulators are known from simple epithelia. We discuss their putative usability for drug delivery into and through the skin. (C) 2008 Elsevier B.V. All rights reserved.