The effects of body mass index on lung volumes
The effects of body mass index on lung volumes
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DOI：
10.1378/chest.130.3.827
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发表时间：
2006-09-01
期刊：
影响因子：
9.6
通讯作者：
Nzekwu, Mary-Magdalene U.
中科院分区：
文献类型：
--
作者：
Jones, Richard L.;Nzekwu, Mary-Magdalene U.
背景：在北美，肥胖是一个主要的健康问题，未来肥胖将成为一个更重要的医疗问题。由于肥胖可引起呼吸系统症状，许多肥胖者被转介进行肺功能检查（pft）。众所周知，肥胖会导致肺容量减少，但从未有大型研究表明身体质量指数（BMI）与各种肺容量之间存在相关性。设计：我们收集了373名接受肺功能检查的患者的PFT结果，这些患者的气道功能正常，但bmi范围很广。环境：PFTs在两个认可的门诊实验室进行。结果：BMI与肺活量和总肺活量之间存在显著的线性关系，但即使是病态肥胖患者，其组平均值也保持在正常范围内。然而，功能剩余容量（FRC）和呼气储备容量（ERV）随着BMI的增加呈指数下降，病态肥胖导致患者呼吸接近其剩余容量。一个重要的发现是，FRC和ERV的最大变化率发生在超重和轻度肥胖的情况下。体重指数为30 kg/m(2)时，FRC和ERV分别仅为体重指数为20 kg/m(2)的瘦人的75%和47%。结论：我们发现BMI对所有肺容量都有显著影响，其中对FRC和ERV的影响最大，发生在BMI值< 30 kg/m时(2)。我们的结果将有助于临床医生解释气道功能正常患者的PFT结果。
Background: Obesity is a major health issue in North America, and the trend is for obesity to be a more important medical issue in the future. Since obesity can cause respiratory symptoms, many obese people are referred for pulmonary function tests (PFTs). It is well known that obesity causes decreases in lung volumes, but there has never been a large study showing the correlation between body mass index (BMI) and the various lung volumes.Design: We collected PFT results from 373 patients sent for lung function testing who had normal values for airway function but a wide range of BMIs.Setting: The PFTs were done in two accredited outpatient laboratories.Results: There were significant linear relationships between BMI and vital capacity and total lung capacity, but the group mean values remained within the normal ranges even for morbidly obese patients. However, functional residual capacity (FRC) and expiratory reserve volume (ERV) decreased exponentially with increasing BMI, such that morbid obesity resulted in patients breathing near their residual volume. An important finding was that the greatest rates of change 2 in FRC and ERV occurred in the overweight condition and in mild obesity. At a BMI of 30 kg/m(2), FRC and ERV were only 75% and 47%, respectively, of the values for a lean person with a BMI of 20 kg/m(2).Conclusions: We showed that BMI has significant effects on all of the lung volumes, and the greatest effects were on FRC and ERV, which occurred at BMI values < 30 kg/m(2). Our results will assist clinicians when interpreting PFT results in patients with normal airway function.