Stereoselective 1,6-Conjugate Addition/Annulation of para-Quinone Methides with Vinyl Epoxides/Cyclopropanes
Stereoselective 1,6-Conjugate Addition/Annulation of para-Quinone Methides with Vinyl Epoxides/Cyclopropanes
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DOI：
10.1021/acscatal.6b01845
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发表时间：
2016-10-01
期刊：
影响因子：
12.9
通讯作者：
Zhao, Yu
中科院分区：
文献类型：
--
作者：
Ma, Chao;Huang, Yuan;Zhao, Yu
在这里，我们提出了前所未有的形式[3+2]环加成对苯二酚甲基与乙烯基环氧化物/环丙烷，以提供高效率和立体选择性的广泛的螺环[4.5]正庚烷。催化剂和试剂的商品化，加上操作简便，使其在不对称合成中成为一种有吸引力的方法。
Here, we present an unprecedented formal [3 + 2] cycloaddition of para-quinone methides with vinyl epoxides/cyclopropanes to deliver a wide range of spiro[4.5]decanes in high efficiency and stereoselectivity. The commercial availability of the catalysts and reagents, together with the convenient procedure, makes it an attractive method in asymmetric synthesis.