BART Cancer: a web resource for transcriptional regulators in cancer genomes.
BART Cancer: a web resource for transcriptional regulators in cancer genomes.
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DOI：
10.1093/narcan/zcab011
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发表时间：
2021-03
期刊：
影响因子：
5.1
通讯作者：
Zang C
中科院分区：
文献类型：
--
作者：
Thomas ZV;Wang Z;Zang C
基因表达失调在肿瘤的发生发展中起着重要作用。确定转录调节因子和染色质调节因子，驱动致癌基因表达程序是癌症研究中的一项关键任务。来自原发癌样本的活性转录调节因子的基因组图谱在公共领域是有限的。在这里，我们介绍了BART癌症(bartancer.org)，这是一个交互式网络资源数据库，用于显示在癌症基因组图谱(TCGA)中15种不同癌症类型中负责差异调控基因的假定转录调控因子。BART癌症集成了来自TCGA的10000多个基因表达谱RNA-SEQ数据集与来自Cistrome数据浏览器数据库和基因表达总览(GEO)的7,000多个CHIP-SEQ数据集。BART癌症使用转录调控结合分析(BART)来预测癌症样本中与正常样本相比差异表达的基因的转录调控因子。通过整合BART和Cistrome癌症数据库的计算预测结果，BART癌症还显示了癌症类型中900多个转录调控因子的活动。BART癌症专注于人类癌症中的转录调控活动，可以为癌症的表观遗传学和转录调控提供独特的见解，是基因组学和癌症研究社区的有用数据资源。巴特癌症：癌症基因组转录调控的网络资源。
Dysregulation of gene expression plays an important role in cancer development. Identifying transcriptional regulators, including transcription factors and chromatin regulators, that drive the oncogenic gene expression program is a critical task in cancer research. Genomic profiles of active transcriptional regulators from primary cancer samples are limited in the public domain. Here we present BART Cancer (bartcancer.org), an interactive web resource database to display the putative transcriptional regulators that are responsible for differentially regulated genes in 15 different cancer types in The Cancer Genome Atlas (TCGA). BART Cancer integrates over 10000 gene expression profiling RNA-seq datasets from TCGA with over 7000 ChIP-seq datasets from the Cistrome Data Browser database and the Gene Expression Omnibus (GEO). BART Cancer uses Binding Analysis for Regulation of Transcription (BART) for predicting the transcriptional regulators from the differentially expressed genes in cancer samples compared to normal samples. BART Cancer also displays the activities of over 900 transcriptional regulators across cancer types, by integrating computational prediction results from BART and the Cistrome Cancer database. Focusing on transcriptional regulator activities in human cancers, BART Cancer can provide unique insights into epigenetics and transcriptional regulation in cancer, and is a useful data resource for genomics and cancer research communities. BART Cancer: a web resource for transcriptional regulators in cancer genomes.