Effects of mucosal removal on guinea-pig airway smooth muscle responsiveness.
Effects of mucosal removal on guinea-pig airway smooth muscle responsiveness.
复制标题
粘膜去除对豚鼠气道平滑肌反应性的影响。
DOI：
10.1042/cs0700571
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Murlas,C
中科院分区：
文献类型：
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作者：
Murlas,C
在成对的气管环中检查对组胺、乙酰胆碱 (ACh)、KCl 或电场刺激 (EFS) 的收缩反应（每个气管环通过粘膜摩擦剥落），气管环安装在充满 37°C 连续通气的生理盐溶液的肌肉室中。去除呼吸道粘膜增加了气道肌肉对 ACh、组胺和 EFS 的敏感性，但不增加对 KCl 的敏感性。裸露环对组胺和EFS的超敏性高于对ACh的超敏性。阿托品降低了观察到的组胺超敏反应。用吲哚美辛预处理完整制剂可增强其对 EFS、组胺和乙酰胆碱的反应性。在没有上皮的制剂中，吲哚美辛对组胺和 EFS 诱导的反应的增强作用更大。我们的结论是，气道粘膜可能与降低气道平滑肌对刺激反应性的因素有关。
The contractile response to histamine, acetylcholine (ACh), KCl or electrical field stimulation (EFS) was examined in paired tracheal rings (one of each being denuded by mucosal rubbing), which were mounted in muscle chambers filled with a continuously aerated physiological salt solution at 37 degrees C. Removal of the respiratory mucosa increased the sensitivity of airways muscle to ACh, histamine and EFS, but not to KCl. The hypersensitivity of denuded rings to histamine and EFS was greater than to ACh. Atropine reduced the histamine hypersensitivity observed. Pretreating intact preparations with indomethacin augmented their responsiveness to EFS, histamine and ACh. Indomethacin augmentation of histamine-and EFS-induced responses was greater in preparations without epithelium. We conclude that the airway mucosa may be associated with a factor that reduces airway smooth muscle responsiveness to stimulation.