BOTULINUM-A TOXIN FOR CRANIAL-CERVICAL DYSTONIA - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
BOTULINUM-A TOXIN FOR CRANIAL-CERVICAL DYSTONIA - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
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DOI：
10.1212/wnl.37.4.616
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发表时间：
1987-04-01
期刊：
影响因子：
9.9
通讯作者：
ORMAN, J
中科院分区：
文献类型：
--
作者：
JANKOVIC, J;ORMAN, J
我们以双盲方式研究了12例眼睑痉挛和10例口颌颈肌张力障碍患者接受A型肉毒毒素治疗的效果。所有眼睑痉挛患者的临床评分均有所改善，其中71.6%的患者通过自我评估获得改善，60.7%的患者通过视频评分获得改善，38.9%的患者通过视频评分获得改善;安慰剂组没有改善。有益效果平均持续12.5周（范围，5至28周）。只有37.5%的口颌颈肌张力障碍患者得到改善。咽肌张力障碍和痉挛性发音困难的患者也得到改善。
We studied the effects of botulinum A toxin in 12 patients with blepharospasm and 10 patients with oromandibular-cervical dystonia received in a double-blind manner. All blepharospasm patients improved, 71.6% on a clinical rating score, 60.7% by self-assessment, and 38.9% by video-rating; there was no improvement with placebo. The beneficial effects lasted a mean of 12.5 weeks (range, 5 to 28). Only 37.5% of the patients with oromandibular-cervical dystonia improved. Patients with pharyngeal dystonia and spasmodic dysphonia also improved.