Estrogen enhances performance of female rats during acquisition of a radial arm maze
Estrogen enhances performance of female rats during acquisition of a radial arm maze
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DOI：
10.1006/hbeh.1997.1433
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发表时间：
1997-12-01
影响因子：
3.5
通讯作者：
Dohanich, GP
中科院分区：
文献类型：
--
作者：
Daniel, JM;Fader, AJ;Dohanich, GP
雌激素可以影响与生殖没有直接关系的行为，包括学习和记忆。然而，雌激素对哺乳动物学习和记忆的影响是复杂的，取决于多种因素。桡臂迷宫是一种传统的实验任务，它利用了大鼠的自然觅食策略，并为研究雌激素对该物种工作记忆的影响提供了适当的措施。在这里报告的实验中，卵巢切除大鼠皮下植入5毫米硅橡胶胶囊含有25%雌二醇稀释胆固醇。对照组雌性动物接受含100%胆固醇的5 mm硅橡胶胶囊。三个独立实验的结果表明，与仅用胆固醇治疗的雌性动物相比，在八臂径向迷宫训练之前30天、在24天迷宫训练期间或两者同时通过硅橡胶植入物给予雌二醇显著改善了工作记忆表现，如试验中改善的手臂选择准确性所示。在训练前暴露于雌二醇的积极作用表明，雌激素可能会诱导神经元的变化，这些变化持续超过暴露期，并对行为产生功能性影响，（C）1997年学术出版社。
Estrogen can influence the expression of behaviors not associated directly with reproduction, including learning and memory. However, the effects of estrogen on learning and memory in mammals are complex, dependent on a variety of factors. The radial arm maze is a traditional experimental task that takes advantage of the natural foraging strategy of rats and provides an appropriate measure for studying the effects of estrogen on working memory in this species. In the experiments reported here, ovariectomized rats were implanted subcutaneously with 5-mm Silastic capsules containing 25% estradiol diluted with cholesterol. Control females received 5-mm Silastic capsules containing 100% cholesterol. Results of three separate experiments demonstrated that estradiol administered by Silastic implants for 30 days prior to eight-arm radial maze training, during the 24 days of maze training, or both significantly improved working memory performance compared to females treated with cholesterol alone, as indicated by improved arm choice accuracy over trials. The positive effect of estradiol exposure prior to training suggests that estrogen may induce neuronal changes that persist beyond the period of exposure with functional consequences for behavior, (C) 1997 Academic Press.