Effect of ryanodine on calcium in cardiac muscle.
Effect of ryanodine on calcium in cardiac muscle.
复制标题
兰尼定对心肌钙的影响。
作者：
W. Nayler;P. Daile;D. Chipperfield;K. Gan
温妮弗雷德·奈勒P. Daile，Denise Chipperfield，and K.乾兰尼碱对心肌钙离子的影响。Am. J. Physiol.219（6）：1620-1626。1970.-兰尼定对哺乳动物心肌的负性肌力作用伴随着收缩过程中峰值张力形成所需时间的高度显著变化。放松减慢。45 ca的内流保持不变，4 Qa外流显著增强。心肌肌管的45 Ca积累活性降低，Ca ++依赖性（但不是碱性ATP酶）活性增加，表明兰尼定使ATP水解和Ca++摄取解偶联。肌钙蛋白的Ca++结合能力不变。
NAYLER, WINIFRED G., P. DAILE, DENISE CHIPPERFIELD, AND AND K. GAN. E&t of ryanodine on calcium in cardiac muscle. Am. j. Physiol. 219(6): 1620-1626. 1970.-The negative inotropic effect of ryanodine on mammalian heart muscle is accompanied by highly significant changes in time taken during contraction for peak tension to develop. Relaxation is slowed. Influx of 45ca remains unchanged and 4Qa efflux is significantly enhanced. The 45Ca accumulating activity of cardiac sarcotubules is diminished and the activity of the Ca ++-dependent (but not of the basic ATPase enzyme) increases, indicating that ryanodine uncouples ATP hydrolysis and Ca++ uptake. The Ca++-binding capacity of troponin is not changed.