Bioactive constituents of oleanane-type triterpene saponins from the roots of Glycyrrhiza glabra
Bioactive constituents of oleanane-type triterpene saponins from the roots of Glycyrrhiza glabra
复制标题
光果甘草根中齐墩果烷型三萜皂苷的生物活性成分
DOI：
10.1080/10286020.2014.960857
复制
发表时间：
2014-11-02
影响因子：
1.7
通讯作者：
Peng, Guo-Ping
中科院分区：
文献类型：
--
作者：
Wei, Juan-Hua;Zheng, Yun-Feng;Peng, Guo-Ping
从光果甘草（Corrhiza glabra L.）的根中分离得到3个新的齐墩果烷型三萜皂苷，即甘草皂苷M_3（1）、甘草皂苷N_4（2）和人工产物甘草皂苷O_4（3）（4），以及5个已知的三萜葡萄糖醛酸苷（5-9）。它们的结构是建立使用1D和2D NMR光谱，质谱，并与文献中报道的光谱数据进行比较。评价了所选化合物对神经氨酸酶的抑制作用，并对其构效关系进行了初步预测。
Three new oleanane-type triterpene saponins, namely licorice-saponin M3 (1), licorice-saponin N4 (2), and licorice-saponin O4 (3), an artificial product (4), as well as five known triterpene glucuronides (5-9), were isolated from the roots of Glycyrrhiza glabra L. Their structures were established using 1D and 2D NMR spectroscopy, mass spectrometry, and by comparison with spectroscopic data reported in the literature. The inhibitory effects of the selected compounds on neuraminidase were evaluated, and the preliminary structure-activity relationship was also predicted.