Electroencephalogram slowing predicts neurodegeneration in rapid eye movement sleep behavior disorder
Electroencephalogram slowing predicts neurodegeneration in rapid eye movement sleep behavior disorder
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DOI：
10.1016/j.neurobiolaging.2015.10.007
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Montplaisir, Jacques
中科院分区：
文献类型：
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作者：
Brazete, Jessica Rodrigues;Gagnon, Jean-Francois;Montplaisir, Jacques
大部分患有特发性快速眼动睡眠行为障碍（iRBD）的患者发展为突触核蛋白病，主要是帕金森病、路易体痴呆和多系统萎缩。因此，鉴定iRBD中神经变性的标志物可能具有重要意义。我们的目的是评估在清醒状态下进行的脑电图（EEG）频谱分析对预测iRBD神经退行性疾病发展的有用性。54名iRBD患者，其中28名患有帕金森病，多系统萎缩或路易体痴呆（平均随访时间：3.5年），30名健康对照者在基线时接受了静息状态清醒EEG记录，神经系统检查和神经心理学评估。分析了额叶、中央、顶叶、颞叶和枕叶区域5个频带的绝对和相对频谱功率。计算5个皮质区域的慢-快[（delta + theta）/（beta 1 + beta 2）]功率比和优势枕叶频率作为皮质减慢的指数。与无病患者和对照组相比，发生疾病的患者在所有5个皮质区域显示出更高的绝对δ和θ功率。发生疾病的患者的所有区域的慢-快功率比均高于其他2组。此外，与对照组相比，发生疾病的患者具有较慢的优势枕骨频率。在无疾病iRBD患者和对照组之间观察到的唯一显著差异是iRBD患者的额叶和枕叶区域的绝对Δ功率较高。在后来发展为突触核蛋白病的iRBD患者中，在觉醒期间发现了特定的EEG异常。EEG减慢是iRBD患者神经退行性变的一个有希望的标志物。(C)2016 Elsevier Inc. All rights reserved.
A large proportion of patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) develop a synucleinopathy, mostly Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Therefore, identifying markers of neurodegeneration in iRBD could have major implications. We aimed to assess the usefulness of electroencephalography (EEG) spectral analysis performed during wakefulness for predicting the development of a neurodegenerative disease in iRBD. Fifty-four iRBD patients, 28 of whom developed Parkinson's disease, multiple system atrophy, or dementia with Lewy bodies (mean follow-up: 3.5 years), and 30 healthy controls underwent at baseline a resting-state waking EEG recording, neurological exam, and neuropsychological assessment. Absolute and relative spectral powers were analyzed for 5 frequency bands in frontal, central, parietal, temporal, and occipital regions. The slow-to-fast [(delta + theta)/(beta 1 + beta 2)] power ratio for each of the 5 cortical regions and the dominant occipital frequency were calculated as an index of cortical slowing. Patients who developed disease showed higher absolute delta and theta power in all 5 cortical regions compared to disease-free patients and controls. The slow-to-fast power ratio was higher in all regions in patients who developed disease than in the 2 other groups. Moreover, patients who developed disease had a slower dominant occipital frequency compared to controls. The only significant difference observed between disease-free iRBD patients and controls was higher absolute delta power in frontal and occipital regions in iRBD patients. Specific EEG abnormalities were identified during wakefulness in iRBD patients who later developed a synucleinopathy. EEG slowing is a promising marker of neurodegeneration in iRBD patients. (C) 2016 Elsevier Inc. All rights reserved.