Schizoid personality disorder after prenatal exposure to famine.
Schizoid personality disorder after prenatal exposure to famine.
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DOI：
10.1176/ajp.153.12.1637
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发表时间：
1996-12
期刊：
影响因子：
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通讯作者：
H. Hoek;E. Susser;Buck Ka;L. Lumey;S. Lin;J. Gorman
中科院分区：
文献类型：
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作者：
H. Hoek;E. Susser;Buck Ka;L. Lumey;S. Lin;J. Gorman
目的：作者测试了产前早期暴露于饥荒是否与精神分裂症谱系人格障碍有关，除了与精神分裂症本身有关，如以前的研究所示。方法：比较了在荷兰饥饿冬季饥荒高峰时出生的队列和1944-1946年荷兰饥荒地区未暴露的出生队列中18岁男性患ICD-6至ICD-9定义的类抑郁性人格障碍的风险。结果：暴露组人群患类抑郁性人格障碍的危险性显著增高（相对危险度= 2.01）。结论：产前营养缺乏与18岁男性患类抑郁性人格障碍的风险更大有关。
OBJECTIVE The authors tested whether early prenatal exposure to famine was associated with schizophrenia spectrum personality disorder in addition to being associated with schizophrenia per se as shown in a previous study. METHOD The risk of schizoid personality disorder, as defined by ICD-6 to ICD-9, in men at age 18 years was compared in birth cohorts that were conceived at the height of the Dutch Hunger Winter famine and in unexposed birth cohorts of 1944-1946 in the famine region of Holland. RESULTS The exposed cohort had a significantly greater risk (relative risk = 2.01) of schizoid personality disorder. CONCLUSIONS Prenatal nutritional deficiency was associated with a greater risk of schizoid personality disorder in men at age 18 years.