ON THE STATISTICAL DETERMINATION OF MAJOR GENE MECHANISMS IN CONTINUOUS HUMAN TRAITS - REGRESSIVE MODELS
ON THE STATISTICAL DETERMINATION OF MAJOR GENE MECHANISMS IN CONTINUOUS HUMAN TRAITS - REGRESSIVE MODELS
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DOI：
10.1002/ajmg.1320180420
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
BONNEY, GE
中科院分区：
文献类型：
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作者：
BONNEY, GE
对人类家系和家系的一个连续性状进行了分析，以阐明潜在的主效基因的机制。根据家系相关性的自然马尔科夫结构而不是方差分量的思想，描述了在计算上可行的回归模型的自然类。这些模型可以适应对残差变异的广泛概括，因此应该为推断主基因的分离和连锁关系提供比迄今提出的其他模型更强的基础。
A continuous trait measured on human families and pedigrees was analyzed to elucidate the mechanism of underlying major genes. Thinking in terms of the naturally Markovian structure of the dependencies in pedigrees rather than variance components, natural classes of regressive models that are computationally feasible are described. These models can accommodate wide generalizations of the residual variation, and so should provide a stronger basis than other models proposed to date for inferring the segregation and linkage relationships of major genes.