Acceptability of Oral Preexposure Prophylaxis Among Men Who Have Sex With Men in Philadelphia.
Acceptability of Oral Preexposure Prophylaxis Among Men Who Have Sex With Men in Philadelphia.
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费城男男性行为者口服暴露前预防的可接受性。
DOI：
10.1097/qai.0000000000001139
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Brady,KathleenA
中科院分区：
文献类型：
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作者：
Adams,JoëllaW;Shinefeld,Jennifer;Brady,KathleenA
由BhDMf 5ePHKbH 4 TTImqenVA + lpWIIBvonhQl 60 Etgtdnn 9 T1 vLQWJq/+ R2 O 4Kjt 58于2023年11月15日下载或未使用避孕套，或有商业性工作史。1男性之间的性接触是费城男性中最常见的艾滋病毒传播途径。2014年，费城男性居民中492例新诊断的艾滋病毒病例中有319例（65%）报告MSM为传播风险。2 PrEP有可能预防HIV阴性MSM中的HIV传播，但前提是接受和坚持药物治疗的程度很高。我们使用来自费城国家艾滋病行为监测系统（NHBS）的调查答复，以评估艾滋病毒阴性MSM对PrEP的可接受性以及与使用PrEP意愿相关的特征。特别是，我们试图确定艾滋病毒感染风险最大的MSM人群亚组对PrEP的可接受性，包括在过去一年中有大量性伴侣的男男性行为者和那些从事无保护肛交的人，告知潜在的干预措施。NHBS是一个CDC-资助的国家监测系统，收集美国20个城市中感染艾滋病毒高风险人群的横断面行为数据，包括男男性行为者，注射毒品者，异性恋者感染艾滋病的风险增加。我们的研究使用了2014年8月至11月在费城进行的第四次NHBS MSM周期的调查问卷。在这一周期内，共对709名男男性行为者进行了访谈。该分析排除了自报HIV阳性（n= 132，18.6%），未完成PrEP使用相关问题（n= 9，1%）或拒绝HIV检测（n= 31，4.4%）的受访者。最终研究人群包括537名MSM。费城的NHBS MSM 4调查补充了一份简短的声明，解释了PrEP和几个后续问题，包括“你愿意每天服用PrEP药丸来降低你感染艾滋病毒的机会吗？”可能的回答包括“是"、“否”和“不知道”。我们的主要结果是对这个问题的肯定回答。HIV阴性男男性接触者报告之前或当前使用PrEP（n= 35，6.5%）也被纳入分析，因为他们愿意服用PrEP。
Downloaded from by BhDMf5ePHKbH4TTImqenVA+ lpWIIBvonhQl60Etgtdnn9T1vLQWJq/+ R2O4Kjt58 on 11/15/2023 or no condom use, or a history of commercial sex work. 1 Male-to-male sexual contact is the most common route of HIV transmission among men in Philadelphia. In 2014, 319 (65%) of the 492 newly diagnosed HIV cases among male Philadelphia residents reported MSM as a transmission risk. 2 PrEP has the potential to prevent HIV transmission among HIV-negative MSM but only if acceptance of and adherence to the medication is high. We used survey responses from the National HIV Behavioral Surveillance System (NHBS) in Philadelphia to evaluate the acceptability of PrEP among HIV-negative MSM and characteristics associated with the willingness to use PrEP. In particular, we sought to identify the acceptability of PrEP among the MSM population subgroups at a greatest risk of HIV acquisition, including MSM with a high number of sexual partners and those engaging in unprotected anal sex in the past year, to inform potential interventions.NHBS is a CDC-funded national surveillance system that collects crosssectional behavioral data in 20 US cities among populations at the high risk for acquiring HIV, including MSM, persons who inject drugs, and heterosexuals at an increased risk for HIV infection. Our study uses survey responses from the fourth NHBS MSM cycle in Philadelphia conducted from August to November 2014. A total of 709 MSM were interviewed during this cycle. This analysis excludes respondents who self-reported being HIV positive (n= 132, 18.6%), did not complete relevant questions regarding PrEP use (n= 9, 1%), or declined HIV testing (n= 31, 4.4%). The final study population includes 537 MSM. Philadelphia’s NHBS MSM4 survey was supplemented with a brief statement explaining PrEP and several follow-up questions including,“Would you be willing to take the pill PrEP every day to lower your chances of getting HIV?” Possible responses included “yes,”“no,” and “don’t know.” Our primary outcome was an affirmative response to this question. HIV-negative MSM reporting prior or current use of PrEP (n= 35, 6.5%) were also included in the analysis as those willing to take PrEP. Associations of the outcome with sociodemographic varia-