Structures, Biological Activities and Total Syntheses of Cyclic Bisbibenzyls from Liverworts
Structures, Biological Activities and Total Syntheses of Cyclic Bisbibenzyls from Liverworts
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DOI：
10.1002/chin.200044256
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发表时间：
2000-07
期刊：
影响因子：
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通讯作者：
Y. Fukuyama;M. Kodama;Y. Asakawa
中科院分区：
文献类型：
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作者：
Y. Fukuyama;M. Kodama;Y. Asakawa
Macrocyclic bisbibenzyls specifically occur in the Hepaticae and have been seldom found in other terrestrial plants. We have found most of over 60 congeners which are known so far. Their structural features, biosynthesis and biological activities as well as their distribution in the liverworts are described. Marchantin A (8) and riccardin B (2) which are representative cyclic bisbibenzyls linked via two biphenyl ether C-O bonds have been synthesized by using the intramolecular Wardsworth-Emmons reaction for macrocyclization. Plagiochins A (33) D (36), another cyclic bisbibenzyls having one biphenyl ether C-O and one biaryl C-C bonds, have been synthesized by the intramolecular Pd (0) catalyzed Stine-kelly reaction of the dibromoperrotetin E derivative 93. All of the synthesized plagiochins have been evaluated on neurotrophic activity by rat cortical neuronal culture.
