Magnesium nitrate attenuates blood pressure rise in SHR rats.
Magnesium nitrate attenuates blood pressure rise in SHR rats.
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DOI：
10.1684/mrh.2014.0358
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发表时间：
2014
影响因子：
3.2
通讯作者：
R. Vilskersts;J. Kuka;E. Liepinsh;H. Cirule;A. Gulbe;I. Kalvinsh;M. Dambrova
中科院分区：
文献类型：
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作者：
R. Vilskersts;J. Kuka;E. Liepinsh;H. Cirule;A. Gulbe;I. Kalvinsh;M. Dambrova
服用镁补充剂和硝酸盐/亚硝酸盐可以降低动脉血压并减轻高血压引起的并发症的发展。本研究旨在探讨硝酸镁治疗对自发性高血压 (SHR) 大鼠高血压及其并发症的影响。将12-13周龄持续性高血压的雄性SHR大鼠根据动脉血压分为两组。对照组大鼠饮用纯净水，第二组实验动物饮用溶解在纯净水中的硝酸镁，剂量为50 mg/kg。治疗四周后，测量血压，使用超声仪记录心脏的解剖和功能参数，在器官浴实验中测定血管反应性，并在离体实验性心肌梗死模型中测定硝酸镁给药的心脏保护作用。硝酸镁治疗显着增加了血浆中硝酸盐浓度（从62±8μmol/L至111±8μmol/L），并减弱了动脉血压的升高。在对照组和硝酸镁组中，血压分别升高了 21 ± 3 mmHg 和 6 ± 4 mmHg。服用硝酸镁对改变的血管反应性、心脏功能或心肌梗塞的面积没有影响。总之，我们的结果表明硝酸镁可以有效减弱动脉血压的升高。然而，可能需要更长的给药时间或更早开始治疗，以延缓高血压并发症的发生。
The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitrate on the development of hypertension and its complications in spontaneously hypertensive (SHR) rats. Male SHR rats with persistent hypertension at the age of 12-13 weeks were allocated to two groups according to their arterial blood pressure. Rats from the control group received purified water, while the experimental animals from the second group received magnesium nitrate dissolved in purified water at a dose of 50 mg/kg. After four weeks of treatment, blood pressure was measured, the anatomical and functional parameters of the heart were recorded using an ultrasonograph, vascular reactivity was assayed in organ bath experiments and the cardioprotective effects of magnesium nitrate administration was assayed in an ex vivo experimental heart infarction model. Treatment with magnesium nitrate significantly increased the nitrate concentration in the plasma (from 62 ± 8 μmol/l to 111 ± 8 μmol/L), and attenuated the increase in the arterial blood pressure. In the control and magnesium nitrate groups, the blood pressure rose by 21 ± 3 mmHg and 6 ± 4 mmHg, respectively. The administration of magnesium nitrate had no effect on the altered vasoreactivity, heart function or the size of the heart infarction. In conclusion, our results demonstrate that magnesium nitrate effectively attenuates the rise in arterial blood pressure. However, a longer period of administration or earlier onset of treatment might be needed to delay the development of complications due to hypertension.