Baseline sodium-lithium countertransport and 6-year incidence of hypertension. The Gubbio Population Study.
Baseline sodium-lithium countertransport and 6-year incidence of hypertension. The Gubbio Population Study.
复制标题
基线钠-锂反转运和 6 年高血压发病率。
DOI：
10.1161/01.cir.95.3.581
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
Stamler,J
中科院分区：
文献类型：
--
作者：
Laurenzi,M;Cirillo,M;Panarelli,W;Trevisan,M;Stamler,R;Dyer,AR;Stamler,J
背景高血压患者钠-锂逆向转运（Na-Li CT）活性高。本研究调查是否高钠锂CT涉及到发展的高血压。方法和结果在基线访问的Gubbio人口研究，4210人的5376调查18至74岁，其中，1599高血压（收缩压≥140毫米汞柱，或舒张压≥90毫米汞柱，或抗高血压药物治疗）。在2611名非高血压患者中，302名未进行钠锂CT测量，580名未参加6年随访。因此，本分析涉及1729例18 - 74岁男性和18 - 74岁女性的数据，这些患者在基线时无高血压，并进行了Na-Li CT测量。与基线和随访时无高血压的个体相比，随访时发生高血压的个体（收缩压≥140 mm Hg，或舒张压≥90 mm Hg，或接受抗高血压药物治疗）的钠锂CT、血压、年龄、体重指数、血浆胆固醇和酒精摄入量的基线值较高（P<0.05）。在四分位数分析中，基线Na-Li CT与高血压的发生呈正相关（P<0.05），Na-Li CT在最高四分位数的男性和女性中高血压的发病率最高（男性，≥376 μmol Li·L红细胞-1·h-1，女性，≥311 μmol Li·L红细胞-1·h-1）。单因素Logistic回归分析显示，高血压的发病率与钠锂CT基线值、血压、年龄、体重指数、血浆胆固醇和饮酒有关（P<0.05）。在多因素logistic回归分析中，控制性别、基线年龄、体重指数、收缩压和其他混杂因素后，基线钠锂CT高127 μmol（男女合并标准差）的个体发生高血压的风险增加1.23倍（P<0.001）。
BackgroundSodium-lithium countertransport (Na-Li CT) activity is high in persons with hypertension. This study investigated whether high Na-Li CT relates to development of hypertension.Methods and ResultsAt the baseline visit of the Gubbio Population Study, 4210 people of the 5376 surveyed were 18 to 74 years old; of these, 1599 were hypertensive (systolic pressure ≥140 mm Hg, or diastolic pressure ≥90 mm Hg, or on antihypertensive drug therapy). Of the 2611 nonhypertensives, 302 did not have Na-Li CT measured and 580 did not participate in 6-year follow-up. This analysis, therefore, deals with data collected on 1729 men 18 to 74 years old and women 18 to 74 years old who at baseline were nonhypertensive and had Na-Li CT measurement. Compared with individuals who were nonhypertensive at baseline and follow-up, individuals with incident hypertension at follow-up (systolic pressure ≥140 mm Hg, or diastolic pressure ≥90 mm Hg, or on antihypertensive drug therapy) had higher baseline values of Na-Li CT, blood pressure, age, body mass index, plasma cholesterol, and alcohol intake (P<.05). Baseline Na-Li CT was positively associated (P<.05) with development of hypertension in quartile analysis, with highest incidence of hypertension among men and women with Na-Li CT in the highest quartile (for men, ≥376 and for women, ≥311 μmol Li·L red blood cells−1·h−1). In univariate logistic regression, incidence of hypertension was related to baseline value of Na-Li CT, blood pressure, age, body mass index, plasma cholesterol, and alcohol intake (P<.05). In multiple logistic regression analysis, individuals with baseline Na-Li CT higher by 127 μmol (pooled SD for men and women) had 1.23 times greater risk of incident hypertension with control for sex and baseline age, body mass index, systolic pressure, and other confounders (P<.001).ConclusionsNa-Li CT is a predictor of hypertension risk in adults.