The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis.
The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis.
复制标题
现场活疫苗针对被忽视的人畜共患病和牛结核病的病例。
DOI：
10.1371/journal.pntd.0004572
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发表时间：
2016-08
影响因子：
3.8
通讯作者：
de Figueiredo P
中科院分区：
文献类型：
--
作者：
Pandey A;Cabello A;Akoolo L;Rice-Ficht A;Arenas-Gamboa A;McMurray D;Ficht TA;de Figueiredo P
用减毒活生物体对人类和动物进行疫苗接种已被证明是对抗一些重要传染病的有效手段。事实上，世纪见证了全球人类和动物健康的巨大改善，这是使用减毒活疫苗（LAV）的大规模疫苗接种计划的结果。在这里，我们使用被忽视的人畜共患疾病布鲁氏菌病和牛结核病（BTb）引起的布鲁氏菌属。和牛分枝杆菌（M.牛），作为比较模型，以概述LAV平台的优点，重点是已经追求的分子策略，以产生具有增强的疫苗安全性和效力概况的LAV。最后，我们讨论了LAV平台在对抗布鲁氏菌病和BTb方面的前景，并概述了未来研究的新途径，以开发使用LAV平台的有效疫苗。
Vaccination of humans and animals with live attenuated organisms has proven to be an effective means of combatting some important infectious diseases. In fact, the 20th century witnessed tremendous improvements in human and animal health worldwide as a consequence of large-scale vaccination programs with live attenuated vaccines (LAVs). Here, we use the neglected zoonotic diseases brucellosis and bovine tuberculosis (BTb) caused by Brucella spp. and Mycobacterium bovis (M. bovis), respectively, as comparative models to outline the merits of LAV platforms with emphasis on molecular strategies that have been pursued to generate LAVs with enhanced vaccine safety and efficacy profiles. Finally, we discuss the prospects of LAV platforms in the fight against brucellosis and BTb and outline new avenues for future research towards developing effective vaccines using LAV platforms.