Near-infrared spectroscopic study and the Wada test for presurgical evaluation of expressive and receptive language functions in glioma patients: With a case report of dissociated language functions
Near-infrared spectroscopic study and the Wada test for presurgical evaluation of expressive and receptive language functions in glioma patients: With a case report of dissociated language functions
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DOI：
10.1016/j.neulet.2012.01.011
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发表时间：
2012-02-29
影响因子：
2.5
通讯作者：
Fujii, Yukihiko
中科院分区：
文献类型：
--
作者：
Sato, Yosuke;Uzuka, Takeo;Fujii, Yukihiko
近红外光谱（NIRS）已被证明是有用的评估语言偏侧在健康受试者，婴儿和癫痫患者。本研究首次采用近红外光谱技术对术前胶质瘤患者的语言表达功能和语言接受功能进行了研究。我们还描述了一个特殊的情况下，分离模式的语言功能。检查了10例胶质瘤患者。采用近红外光谱技术，在动词生成任务或故事听任务中测量了覆盖语言区的大脑半球的血流动力学变化。在NIRS研究之后，对所有患者进行Wada试验。近红外光谱研究显示，在两个任务引起的语言区域的氧合血红蛋白增加和脱氧血红蛋白减少。9例患者均为右利手，语言表达和接受功能均偏向左半球。近红外光谱研究结果与和田试验结果完全一致。在剩下的1例右利手的右侧岛叶胶质瘤患者中，NIRS研究显示在动词生成任务期间右下额叶区的激活更强，在故事听任务期间左上级颞区的激活更强。这种分离的语言功能通过Wada测试和术后神经过程进行了验证。这些结果表明，近红外光谱研究使用我们的技术是非常有价值的术前评估的语言功能，并阐明了如何术前近红外光谱研究可以允许检测不可预见的语言偏侧化。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Near-infrared spectroscopy (NIRS) has proven to be useful for the evaluation of language lateralization in healthy subjects, infants, and epileptic patients. This study for the first time investigated the expressive and receptive language functions separately, using NIRS in presurgical glioma patients. We also describe a special case with dissociated pattern of language functions. Ten glioma patients were examined. Using NIRS, the hemodynamic changes during a verb generation task or story listening task were measured in the cerebral hemisphere on either side covering the language areas. Following the NIRS study, the Wada test was performed in all the patients. The NIRS study revealed increases of oxyhemoglobin and decreases of deoxyhemoglobin in the language areas elicited by both tasks. In 9 patients, who were all right-handed, the expressive and receptive language functions were lateralized to the left hemisphere. The results of the NIRS study were completely consistent with those of the Wada test. In the remaining 1 patient with a right sided insular glioma, who was right-handed, the NIRS study revealed stronger activation of the right inferior frontal region during the verb generation task, and stronger activation of the left superior temporal region during the story listening task. This dissociated language function was validated by the Wada test and the postoperative neurological course. These results demonstrate that a NIRS study using our technique is extremely valuable for preoperative assessment of the language functions and exemplifies how a preoperative NIRS study can allow detection of unforeseen language lateralization. (C) 2012 Elsevier Ireland Ltd. All rights reserved.