The effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on obstructed rat bladder.
The effect of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism on obstructed rat bladder.
复制标题
血管紧张素转换酶抑制和血管紧张素II受体拮抗作用对大鼠膀胱梗阻的影响。
DOI：
10.1097/00005392-199709000-00105
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Cheng,EY
中科院分区：
文献类型：
--
作者：
Palmer,LS;Lee,C;Decker,RS;Lang,S;Kaplan,WE;Firlit,CF;Cheng,EY
PurposeOthers have demonstrated that inhibition of angiotensin II production partially ameliorates obstructive changes in the neonatal rabbit bladder. We examined the effect of angiotensin II converting enzyme inhibition and receptor antagonism on the obstructed rat bladder.Materials and MethodsThree groups of animals were investigated. Partial bladder neck obstruction was created in 23 rats by placing a 2-zero silk ligature around the vesicourethral junction. Eight rats were given untreated tap water, 9 were given water supplemented with 50 mg./kg. of the angiotensin-converting enzyme inhibitor captopril and 6 were given water with 30 mg./kg. of the angiotensin II subtype AT1 receptor antagonist losartan potassium. Eight unobstructed rats served as controls. After 2 weeks of partial outlet obstruction the animals were sacrificed and bladders were harvested. Routine histological evaluation and assays for total protein, deoxyribonucleic acid and collagen content were performed.ResultsHistological evaluation revealed that administration of captopril or losartan potassium resulted in a mild decrease in the degree of obstructive bladder changes. Biochemically neither captopril nor losartan potassium caused a significant decrease in the amount of total deoxyribonucleic acid, protein or collagen content per bladder compared to untreated obstructed bladders.ConclusionsIn contrast to previous studies in neonatal rabbits, neither captopril nor losartan potassium significantly ameliorated the histological or biochemical features of partial bladder outlet obstruction in the rat. Further investigation is necessary into species specific differences to understand better the role that angiotensin II may have in mediating the bladder changes of experimentally induced obstruction.
