5 FACTOR MODEL OF SCHIZOPHRENIA - REPLICATION ACROSS SAMPLES
5 FACTOR MODEL OF SCHIZOPHRENIA - REPLICATION ACROSS SAMPLES
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DOI：
10.1016/0920-9964(94)00041-6
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发表时间：
1995-02-01
影响因子：
4.5
通讯作者：
HYMAN, RB
中科院分区：
文献类型：
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作者：
LINDENMAYER, JP;GROCHOWSKI, S;HYMAN, RB
为探讨抗精神病药对精神分裂症症状学因素结构的影响，对参加多中心II期药物研究的517例DSM-III-R精神分裂症住院患者在阳性和阴性症状量表(PANSS)筛查时和停药一周后对既往抗精神病药进行评估。在每个时间点对PANSS进行单独的主成分分析。使用配对t检验评估PANSS总分和分量分的差异。这两个因素分析都证实了五因素模型(消极、积极、认知、兴奋和抑郁成分)可以解释每个时间点的51.7%和56.2%的变异。用药后，以PANSS总分和每个组成部分衡量，洗出精神病理显着恶化。各组成部分得分的整体恶化似乎是全球性的和一致的，事实证明，在淘汰时，大多数组成部分的单个组成部分得分占总精神病理学得分的比例保持不变。大多数成分缺乏与精神病理总数成比例的变化，这是患者在服用和停用抗精神病药物时这些个体精神病理维度稳定性的证据。研究结果进一步支持了PANSS量表测量的精神分裂症精神病理学五因素模型的有效性。
In order to examine the effect of neuroleptic medication on the factor structure of schizophrenic symptomatology, 517 DSM-III-R schizophrenic in-patients enrolled in a multicenter phase II drug study were evaluated on their preexisting neuroleptic at screening on the Positive and Negative Syndrome Scale (PANSS) and after a one-week drug-free period. Separate principal components analyses of the PANSS were done at each time point. PANSS total and component scores were assessed for differences utilizing paired t-tests. Both factor analyses confirmed the five factor model (negative, positive, cognitive, excitement and depression components) explaining 51.7 and 56.2% of the variances at each time point. After medication wash-out psychopathology significantly worsened as measured by total PANSS score and by each of the components. The overall worsening of component scores appeared global and uniform, as evidenced by the fact that at washout, the proportion of individual component scores to total psychopathology remained constant for most components. The lack of change of most components in proportion to the psychopathology total is evidence for the stability of these individual psychopathological dimensions of patients while on and off neuroleptics. The results further support the validity of the five-factor model of schizophrenic psychopathology as measured by the PANSS.