Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
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DOI：
10.1016/j.ajhg.2013.07.007
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发表时间：
2013-09-05
影响因子：
9.8
通讯作者：
Keller, Matthew C.
中科院分区：
文献类型：
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作者：
de Candia, Teresa R.;Lee, S. Hong;Keller, Matthew C.
为了调查由SNP标记的精神分裂症加性遗传变异的比例在欧洲和非洲血统人群中共享的程度，我们分析了最大的非洲血统组合。（AD [n = 2，142]）和欧洲血统（艾德[n = 4，990]）精神分裂症病例对照全基因组关联研究（GWAS）数据集可用，精神分裂症的分子遗传学（MGS）数据集。我们展示了如何使用测量的SNP的基因组相似性来估计性状之间的加性遗传相关性（SNP相关性[SNP-r（g）]）的方法可以扩展到估计种族之间相同性状的SNP-r（g）。我们估计MGS艾德和MGS AD样本之间精神分裂症的SNP-r（g）为0.66（SE = 0.23），与0（P（SNP-rg（= 0））= 0.0003）有显著差异，但与1（p（（SNP-rg = 1））= 0.26）无显著差异。我们重新估计独立艾德数据集（n = 6，665）和MGS AD样本之间的SNP-r（g）为0.61（SE = 0.21，P（SNP-rg = 0）= 0.0003，p（（SNP-rg = 1））= 0.16）。这些结果表明，许多精神分裂症的风险等位基因是共享的种族群体和非洲-欧洲分歧之前。
To investigate the extent to which the proportion of schizophrenia's additive genetic variation tagged by SNPs is shared by populations of European and African descent, we analyzed the largest combined African descent (AD [n = 2,142]) and European descent (ED [n = 4,990]) schizophrenia case-control genome-wide association study (GWAS) data set available, the Molecular Genetics of Schizophrenia (MGS) data set. We show how a method that uses genomic similarities at measured SNPs to estimate the additive genetic correlation (SNP correlation [SNP-r(g)]) between traits can be extended to estimate SNP-r(g) for the same trait between ethnicities. We estimated SNP-r(g) for schizophrenia between the MGS ED and MGS AD samples to be 0.66 (SE = 0.23), which is significantly different from 0 (P(SNP-rg (= 0)) = 0.0003), but not 1 (p((SNP-rg = 1)) = 0.26). We re-estimated SNP-r(g) between an independent ED data set (n = 6,665) and the MGS AD sample to be 0.61 (SE = 0.21, P(SNP-rg = 0) = 0.0003, p((SNP-rg = 1)) = 0.16). These results suggest that many schizophrenia risk alleles are shared across ethnic groups and predate African-European divergence.