MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis
MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis
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DOI：
10.3109/0886022x.2015.1074474
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发表时间：
2015-10-21
期刊：
影响因子：
3
通讯作者：
Ozaltin, Fatih
中科院分区：
文献类型：
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作者：
Besbas, Nesrin;Kalyoncu, Mukaddes;Ozaltin, Fatih
单核细胞趋化蛋白-1（MCP-1）是一种高度特异性的单核细胞趋化因子，在多种肾脏疾病的发病机制中发挥重要作用。本研究的目的是探讨MCP 1 2518 A/G多态性对儿童局灶节段性肾小球硬化（FSGS）发病率和临床病程的影响。采用PCR-RFLP方法对60例经病理证实的FSGS、76例激素敏感性肾病综合征（SSNS）和96例健康儿童进行MCP 1 2518 A/G基因型检测。采用酶联免疫吸附试验（ELISA）检测所有患者尿液和血清中MCP-1水平，并分析基因型与MCP-1水平及临床预后的相关性。MCP 1基因型频率在所有组中相似。AA等位基因患者发生慢性肾功能衰竭的比例高于GA或GG等位基因患者（分别为46%和35%，p
Monocyte chemoattractant protein-1 (MCP-1) is a highly specific chemokine for monocytes and plays roles in pathogenesis of various renal diseases. The aim of this study is to investigate the effect of MCP1 2518 A/G polymorphism on the incidence and clinical course of focal segmental glomerulosclerosis (FSGS) in children. MCP1 2518 A/G genotype was identified by PCR-RFLP in 60 biopsy-proven FSGS patients, 76 steroid sensitive nephrotic syndrome (SSNS) patients, and 96 healthy children. MCP-1 levels in urine and serum were measured by ELISA in all patients and the correlations of genotype with MCP-1 levels and clinical outcome were evaluated. The genotype frequencies for MCP1 were similar in all groups. The percentage of patients who develop chronic renal failure was higher in patients with AA allele compared to GA or GG alleles (46% vs. 35% respectively, p