Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ
Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ
复制标题
DOI：
10.1126/science.256.5055.370
复制
发表时间：
1992-04
期刊：
影响因子：
56.9
通讯作者：
M. Wegner;Z. Cao;M. Rosenfeld
中科院分区：
文献类型：
--
作者：
M. Wegner;Z. Cao;M. Rosenfeld
细胞内钙水平的改变激活了几条信号转导途径，导致不同的基因表达模式。在这里，钙介导的信号通路被证明涉及C/EBPβ，转录因子的bZip家族的成员。在垂体细胞中，C/EBPβ被磷酸化以响应细胞内钙浓度的增加，这是钙-钙调蛋白依赖性蛋白激酶激活的结果。C/EBPβ亮氨酸拉链内276位丝氨酸的磷酸化似乎赋予包含C/EBPβ结合位点的启动子钙调节的转录刺激。
Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBPβ, a member of the bZip family of transcription factors. In pituitary cells C/EBPβ was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin— dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBPβ appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBPβ.