Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force.
Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force.
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DOI：
10.14283/jfa.2021.5
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Vellas B
中科院分区：
文献类型：
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作者：
LeBrasseur NK;de Cabo R;Fielding R;Ferrucci L;Rodriguez-Manas L;Viña J;Vellas B
国际衰弱和肌肉减少症研究工作组于 2020 年 3 月在 COVID-19 大流行的阴影下召开会议，讨论推进老年科学跨学科领域的策略。老年科学探索衰老的生物机制，作为干预的目标，可以延缓衰老的生理后果、维持功能并预防虚弱和残疾。临床实践和研究的重点包括识别和验证一系列衰老标志的生物标志物。讨论的潜在生物标志物包括线粒体功能障碍、蛋白质稳态、干细胞功能障碍、营养感应、基因组不稳定性、端粒功能障碍、细胞衰老和表观遗传变化的标志物。 FRAILOMICS 计划正在通过各种组学研究探索其中的许多内容。美国国家老龄化研究所转化老年学分会正在致力于将这些知识转化为新疗法。工作组发现的研究差距包括需要改进的细胞和动物模型以及更可靠和敏感的措施。
The International Conference on Frailty and Sarcopenia Research Task Force met in March 2020, in the shadow of the COVID-19 pandemic, to discuss strategies for advancing the interdisciplinary field of geroscience. Geroscience explores biological mechanisms of aging as targets for intervention that may delay the physiological consequences of aging, maintain function, and prevent frailty and disability. Priorities for clinical practice and research include identifying and validating a range of biomarkers of the hallmarks of aging. Potential biomarkers discussed included markers of mitochondrial dysfunction, proteostasis, stem cell dysfunction, nutrient sensing, genomic instability, telomere dysfunction, cellular senescence, and epigenetic changes. The FRAILOMICS initiative is exploring many of these through various omics studies. Translating this knowledge into new therapies is being addressed by the U.S. National Institute on Aging Translational Gerontology Branch. Research gaps identified by the Task Force include the need for improved cellular and animal models as well as more reliable and sensitive measures.