Aeruginosins, protease inhibitors from the cyanobacterium Microcystis aeruginosa
Aeruginosins, protease inhibitors from the cyanobacterium Microcystis aeruginosa
复制标题
DOI：
10.1016/s0040-4020(99)00621-3
复制
发表时间：
1999-09-03
期刊：
影响因子：
2.1
通讯作者：
Murakami, M
中科院分区：
文献类型：
--
作者：
Ishida, K;Okita, Y;Murakami, M
从蓝细菌铜绿微囊藻中分离出五种新的蛋白酶抑制剂，分别与绿脓菌素298-A（5）、98-A（1）和98-B（2）相关。Aerodynosins 98-C（3）和101（4）在Hpla单位中不同于1。5例患者中的Aerodorosin 298-B（6）缺乏阿替诺单位。由于存在缩醛单元，在HPLC中以互变异构体的形式观察到Aerodorosins 89-A（7）和89-B（8）。根据降解产物的光谱数据和色谱分析确定结构3、4和6-8。1-8的绝对立体化学是通过光谱和化学研究相结合推导出来的。(C)1999爱思唯尔科技有限公司。保留所有权利。
Five new protease inhibitors, related to aeruginosins 298-A (5), 98-A (1) and 98-B (2), were isolated from the cyanobacterium Microcystis aeruginosa. Aeruginosins 98-C (3) and 101 (4) differed from 1 in the Hpla unit. Aeruginosin 298-B (6) lacked the argininol unit in 5. Aeruginosins 89-A (7) and 89-B (8) were observed as the tautomers in HPLC because of the presence of the argininal units. Structures 3, 4 and 6-8 were determined on the basis of spectral data and chromatographic analyses of degradation products. The absolute stereochemistry of 1-8 was deduced by a combination of spectral and chemical studies. (C) 1999 Elsevier Science Ltd. All rights reserved.