New approach to frictional phenomena by condensed matter physics
New approach to frictional phenomena by condensed matter physics
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DOI：
10.1007/s10038-003-0099-y
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发表时间：
2004-01-01
影响因子：
--
通讯作者：
Matsukawa, H
中科院分区：
文献类型：
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作者：
Matsukawa, H
前列腺癌（PC）是西方国家癌症死亡的最常见原因之一，并且PC的家族聚集性是众所周知的。在西方国家已经报道了多个PC易感基因座，但在独立数据集中确认基因座的尝试已被证明是不一致的。我们对53个受影响的同胞对进行了全基因组连锁分析，以确定日本人群中与PC相关的遗传位点。两个连锁分析，GENEHUNTER-PLUS和SIBPAL，并检测名义上的统计学意义的连锁PC在染色体1 p和8 p，这是报告为位点的PC在高加索人。连锁的最佳证据在8 p23的D8 S550附近检测到（最大Z（lr）=2.25，P=0.037），第二佳证据在1 p36的D1 S2667附近观察到（最大Z（lr）=2.24，P=0.034）。这是日本人第一次对PC进行遗传作图，结果表明，PC的亲合性与8 p23上的D8 S550和1 p36上的D1 S2667接近。
Prostate cancer (PC) is one of the most common causes of cancer mortality in Western countries, and familial aggregation of PC is well known. Multiple PC susceptibility loci have been reported in Western countries, but attempts to confirm the loci in independent data sets have proven to be inconsistent. We performed a genomewide linkage analysis with 53 affected sib pairs to identify genetic loci related to PC in a Japanese population. Two linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to PC at chromosome 1p and 8p, which were reported as being loci for PC in Caucasians. The best evidence of linkage was detected near D8S550 on 8p23 (maximum Z(lr)=2.25, P=0.037), and the second-best evidence of linkage was observed near D1S2667 on 1p36 (maximum Z(lr)=2.24, P=0.034). This is the first genetic mapping of PC in Japanese, and the results suggest that susceptibilities to PC lie close to D8S550 on 8p23 and D1S2667 on 1p36.