The Effect of Birth Weight on Lung Spirometry in White, School-Aged Children and Adolescents Born at Term: A Longitudinal Population Based Observational Cohort Study
The Effect of Birth Weight on Lung Spirometry in White, School-Aged Children and Adolescents Born at Term: A Longitudinal Population Based Observational Cohort Study
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DOI：
10.1016/j.jpeds.2015.01.002
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发表时间：
2015-05-01
影响因子：
5.1
通讯作者：
Kotecha, Sailesh
中科院分区：
文献类型：
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作者：
Kotecha, Sarah J.;Watkins, W. John;Kotecha, Sailesh
目的 评估出生体重如何影响足月出生儿童儿童期和青春期的肺功能测量。 研究设计 我们使用来自雅芳父母和儿童纵向研究的白人、足月出生、单身人士的数据来确定出生体重与 8-9 岁 (n = 4086) 和 14-17 (n = 2582) 岁肺功能之间的关联。根据性别、身高和年龄调整后的肺功能测量 z 分数，根据根据性别调整的出生体重 z 分数进行建模。此外，模型中还添加了妊娠和头围以及混杂因素（母亲在妊娠期间吸烟和社会阶层）。 结果 在 8-9 岁时，出生体重 z 评分与肺功能 z 评分（1 秒用力呼气量、用力肺活量 [FVC] 以及 FVC 25% 至 75% 之间的用力呼气中期流量）显着相关。当根据妊娠、头围和混杂因素进一步调整出生体重 z 分数时，这些关系基本上没有变化，但用力呼气中期流量在 FVC 的 25% 到 75% 之间除外，在我们调整头围和混杂因素后，该关系不再显着。在 1417 岁时，调整后的出生体重 z 分数和肺量测定 z 分数之间的关联通常不显着。妊娠和性别标准化出生体重每变化 1 公斤，估计 1 秒用力呼气量的差异在 8-9 岁时为 30 mL，在 14-17 岁时为 33 mL。 结论 出生体重与 8-9 岁时足月出生儿童的肺功能相关，但在 1417 岁时则较少，这表明出生体重影响儿童早期的肺功能，但在以后的生活中影响较小。
Objective To evaluate how birth weight affects lung function measurements in childhood and adolescence in term-born children.Study design We used data for white, term-born, singletons, from the Avon Longitudinal Study of Parents and Children to determine the association between birth weight and lung function at age 8-9 (n = 4086) and 14-17 (n = 2582) years. z-scores for lung function measures, adjusted for sex, height, and age, were modeled in terms of birth weight z-score adjusted for sex. In addition, gestation and head circumference then confounders (maternal smoking during pregnancy and social class) were added to the model.Results At age 8-9 years, birth weight z-scores were significantly associated with lung function z-scores (forced expiratory volume in 1 second, forced vital capacity [FVC], and forced mid-expiratory flow between 25% and 75% of FVC). These relationships essentially were unchanged when birth weight z-scores were further adjusted for gestation, head circumference, and confounders, except for forced mid-expiratory flow between 25% and 75% of FVC, which was no longer significant after we adjusted for head circumference and confounders. At age 1417 years, the associations between adjusted birth-weight z-scores and spirometry z-scores were in general not significant. Estimated differences for forced expiratory volume in 1 second were 30 mL at ages 8-9 years and 33 mL at 14-17 years for 1 kg change in birth-weight standardized for gestation and sex.Conclusions Birth weight is associated with lung function in term-born children at 8-9 years, but less so at 1417 years, suggesting that birth weight influences lung function in early childhood but has lesser effect later in life.