3 INDUSTRIAL SOLVENTS INVESTIGATED FOR TUMOR PROMOTING ACTIVITY IN THE RAT-LIVER
3 INDUSTRIAL SOLVENTS INVESTIGATED FOR TUMOR PROMOTING ACTIVITY IN THE RAT-LIVER
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DOI：
10.1016/0304-3835(87)90099-1
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发表时间：
1987-07-01
期刊：
影响因子：
9.7
通讯作者：
HOLMBERG, B
中科院分区：
文献类型：
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作者：
LUNDBERG, I;HOGBERG, J;HOLMBERG, B
二氧六环，四氯乙烯，三氯乙烯进行了研究，作为大鼠肝改变灶启动子的启动/促进协议。在2/3部分肝切除术后24小时，以二乙基亚硝基胺（30 mg/kg）腹腔注射给药。研究中的化学品每天灌胃给药一次，每周5次，持续7周。末次给药后10天处死动物。将肝切片染色用于γ-谷氨酰转肽酶（GGT）和GGT阳性病灶的数量和总体积进行了研究。二氧六环（1000 mg/kg）显著增加了病灶的数量和总体积，而高剂量三氯乙烯（1100 mg/kg）的影响较小。高剂量的全氯乙烯（1100毫克/公斤）没有影响。
Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosoamine, 30 mg/kg, injected i.p. 24h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 times a week for 7 weeks. Ten days after the last administration the animals were killed. Liver sections were stained for .gamma.-glutamyltranspeptidase (GGT) and the number and total volume of GGT-positive foci was studied. Dioxane (1000 mg/kg) significantly increased the number and total volume of foci while a marginal effect was noted for the high dose of trichloroethylene (1100 mg/kg). A high dose of perchloroethylene (1100 mg/kg) had no effect.