Quantum dot light-emitting diodes as light sources in photomedicine: photodynamic therapy and photobiomodulation
Quantum dot light-emitting diodes as light sources in photomedicine: photodynamic therapy and photobiomodulation
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DOI：
10.1088/2515-7639/ab95e8
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发表时间：
2020-05
期刊：
影响因子：
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通讯作者：
M. A. Triana;Adriana A Restrepo;R. Lanzafame;Peter K. B. Palomaki;Yajie Dong
中科院分区：
文献类型：
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作者：
M. A. Triana;Adriana A Restrepo;R. Lanzafame;Peter K. B. Palomaki;Yajie Dong
由于缺乏合适的商业光源，光动力疗法(PDT)和光生物调节(PBM)在临床上的广泛应用一直受到限制。性价比高的量子点发光二极管(QLED)有望成为非常适合这一细分市场的理想光源，不仅符合所需的外形因素(灵活性、轻量化和均匀的大面积照明)，而且在临床相关的深红色波长具有窄的发射光谱和高功率密度。本文综述了量子发光二极管作为光医学光源的研究进展，特别是作为光动力和光子晶体的光源。首先，我们介绍了QLED在光医学领域作为光源的潜力，简要描述了PDT和PBM光疗的机理和优点，并介绍了柔性QLED(FQLED)相对于传统光源和商业光源的独特特性。然后介绍了利用量子发光二极管和有机发光二极管(OLED)进行光医学的开创性工作和最新研究。综述了用于光医学研究的QLED/OLED的性能和QLED的最新进展。最后，我们讨论了制造高效和稳定的FQLED的材料和设计策略，并提出了在不久的将来将FQLED引入医疗保健和光医学市场的基本要求。预计这一综述将对有兴趣为光医学开发轻便和灵活的光源和/或探索基于OLED/QLED的照明设备的新应用的科学界是全面和有用的。
Widespread clinical adoption of photodynamic therapy (PDT) and photobiomodulation (PBM) has been limited due to the lack of a suitable commercial light source. Cost-effective quantum dot light-emitting diodes (QLEDs) promise to be an ideal light source nicely fitting into this niche, not only complying with desired form factors—flexibility, lightweight, and uniform large area illumination—but with narrow emission spectrum and high power density at clinically relevant deep red wavelengths. This paper is intended to provide a review on the development of QLEDs as a photomedical light source, specifically, for PDT and PBM. First, we introduce the potential of QLEDs as light sources in the photomedical field, briefly describe the mechanisms and benefits of both PDT and PBM phototherapies, and present the unique features of flexible QLEDs (FQLEDs) over conventional and commercial light sources. Then, the pioneering work and state-of-the-art research using QLEDs and organic light emitting diodes (OLEDs) for photomedicine are presented. The performance of QLEDs/OLEDs used in photomedical studies and latest progress on QLEDs are also summarized. Ultimately, we discuss the materials and design strategies for fabrication of efficient and stable FQLEDs, and present the basic requirements for near future introduction of FQLEDs into the healthcare and photomedicine markets. This review is expected to be comprehensive and useful to the scientific community interested in developing lightweight and flexible light sources for photomedicine and/or exploring novel applications for OLED/QLED based lighting devices.