Reducing fetal origins of childhood obesity through maternal smoking cessation during pregnancy: an intervention study.
Reducing fetal origins of childhood obesity through maternal smoking cessation during pregnancy: an intervention study.
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通过母亲怀孕期间戒烟减少儿童肥胖的胎儿起源：一项干预研究。
DOI：
10.1038/s41366-018-0267-y
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Epstein,LeonardH
中科院分区：
文献类型：
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作者：
Wen,Xiaozhong;Eiden,RinaD;Justicia-Linde,FayeE;Wang,Youfa;Higgins,StephenT;Kong,KaiLing;Shittu,AbdalAzizT;Perkins,JacobM;Esadah,Priscilla;Mautner,TaylorE;Epstein,LeonardH
婴儿体重快速增加预示儿童肥胖。我们的目的是估计效应量，并确定关键时间干预辅助戒烟在怀孕期间影响婴儿体重增加。我们在UB妊娠和戒烟研究（布法罗，纽约，美国）中随访了25对母婴。母亲的吸烟状况进行了生化验证和监测，通过怀孕。出生体重和身长从出生记录中提取。研究人员测量婴儿的体重和长度在2周和每月从1至12个月大。采用混合模型拟合婴儿年龄别BMI（ZBMI）轨迹。我们发现戒烟者的婴儿从出生到12个月的ZBMI增加（平均值±标准差，1.13 ± 1.16）低于持续吸烟者的婴儿（2.34 ± 1.40;p= 0.035），Cohen的效应值较大（0.96）。如果在怀孕15至27周之间开始戒烟，婴儿从出生到12个月的ZBMI增加较低（<0.47），但如果在28周戒烟（0.65）并随着时间的推移加速（例如，3.16如果在36周时戒烟）。我们的结论是，母亲在怀孕期间戒烟可以通过减少婴儿体重增加来减少胎儿肥胖的起源，特别是如果在怀孕27周之前戒烟。
Rapid infant weight gain predicts childhood obesity. We aimed to estimate effect size and identify critical timing for intervention-assisted smoking cessation during pregnancy to impact infant weight gain. We followed 25 mother–infant dyads in the UB Pregnancy and Smoking Cessation Study (Buffalo, NY, USA). Maternal smoking status was biochemically verified and monitored through pregnancy. Birth weight and length were extracted from birth records. Research staff measured infant weight and length at 2 weeks and monthly from 1 to 12 months of age. Mixed models were used to fit infant BMI-for-agez-score (ZBMI) trajectories. We found infants of quitters had lower ZBMI gain from birth to 12 months (mean ± SD, 1.13 ± 1.16) than infants of persistent smokers (2.34 ± 1.40;p= 0.035), with Cohen’sdeffect size being large (0.96). The infant ZBMI gain from birth to 12 months was low (<0.47) if smoking cessation was initiated between 15 and 27 weeks of pregnancy, but started to increase if quitting at 28 weeks (0.65) and accelerated with time (e.g., 3.16 if quitting at 36 weeks). We concluded maternal smoking cessation during pregnancy may reduce fetal origins of obesity through reducing infant weight gain, especially if quitting smoking by 27 weeks of pregnancy.