CAPSAICIN AND HISTAMINE ANTAGONIST-SENSITIVE MECHANISMS IN THE IMMEDIATE ALLERGIC REACTION OF PIG AIRWAYS
CAPSAICIN AND HISTAMINE ANTAGONIST-SENSITIVE MECHANISMS IN THE IMMEDIATE ALLERGIC REACTION OF PIG AIRWAYS
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DOI：
10.1111/j.1748-1716.1990.tb08811.x
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发表时间：
1990-01-01
期刊：
影响因子：
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通讯作者：
LUNDBERG, JM
中科院分区：
文献类型：
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作者：
ALVING, K;MATRAN, R;LUNDBERG, JM
研究了猪对猪蛔虫致敏后气道血管和支气管的反应。蛔虫、组胺(H)和辣椒素气雾剂均能明显增加鼻、喉和支气管循环的血流量，使血管阻力降低20-40%。当蛔虫和组胺（而不是辣椒素）被送到肺部时，引起肺部气流阻塞，阻力增加，动态顺应性下降40-70%。用H1和h2受体拮抗剂特非那定和西咪替丁联合对猪进行预处理后，血管和支气管对组胺（减少> 77%）和蛔虫（减少> 58%）的反应都明显减少，但对辣椒素气雾剂没有。研究发现，组胺的支气管收缩仅由H1受体介导，而阻断血管舒张反应需要H1和h2拮抗剂，其中h2受体在支气管循环中更重要，H1受体在喉循环和鼻循环中更重要。此外，在实验前2天，用辣椒素对猪进行全身预处理，辣椒素（80%）、蛔虫（40%）和组胺（50%）气溶胶攻击使血管舒张功能降低。当静脉注射组胺时，辣椒素预处理的脱敏效果要小得多。辣椒素脱敏对蛔虫和组胺攻击后肺阻塞的影响仅限于减少60%的动态顺应性下降和蛔虫攻击后耐药性峰值的延迟。
The airway vascular and bronchial responses were studied in pigs sensitized with Ascaris suum. Ascaris, histamine (H) and capsaicin aerosol all induced a clear-cut increase in blood flow in the nasal, laryngeal and bronchial circulation with a decrease in vascular resistance of 20-40%. When delivered to the lung both ascaris and histamine, but not capsaicin, caused pulmonary airflow obstruction with increase in resistance and a fall in dynamic compliance of 40-70%. After pretreatment of pigs with a combination of the H1- and H2-receptor antagonists terfenadine and cimetidine, the vascular and bronchial responses were strongly reduced to both histamine (by > 77%)and ascaris (by > 58%), but not to capsaicin aerosol. The bronchoconstriction to histamine was found to be mediated by H1-receptors only, white both H1- and H2-antagonists were necessary to block the vasodilatory response, with H2-receptors being more important in the bronchial circulation and H1-receptors being more important in the laryngeal and nasal circulation. Furthermore, when pigs were pretreated with capsaicin systemically 2 days before the experiment, the vasodilatation was decreased upon capasicin (by 80%), ascaris (by > 40%) and histamine (by > 50%) aerosol challenge. When histamine was administered intravenously the desensitizing effect of capsaicin pretreatment was much less pronounced. The effect of capsaicin desensitization on the pulmonary obstruction upon ascaris and histamine challenge was limited to a 60% reduction of the fall in dynamic compliance and a delayed peak in resistance upon ascaris challenge.