Visual Acuity Is Correlated with the Area of the Foveal Avascular Zone in Diabetic Retinopathy and Retinal Vein Occlusion
Visual Acuity Is Correlated with the Area of the Foveal Avascular Zone in Diabetic Retinopathy and Retinal Vein Occlusion
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DOI：
10.1016/j.ophtha.2016.07.008
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发表时间：
2016-11-01
期刊：
影响因子：
13.7
通讯作者：
Freund, K. Bailey
中科院分区：
文献类型：
--
作者：
Balaratnasingam, Chandrakumar;Inoue, Maiko;Freund, K. Bailey
目的：目的：探讨糖尿病视网膜病变（DR）和视网膜静脉阻塞（RVO）患者黄斑中心凹无血管区（FAZ）的面积与视力的相关性。设计：横断面研究。参与者：66例DR患者（65只眼）、视网膜分支静脉阻塞（19只眼）和视网膜中央静脉阻塞（11只眼）的95只眼。方法：结构光学相干断层扫描（OCT）。（OCT;分析了单次访视的OCT血管造影（OCTA; Avanti，Optovue RTVue XR）数据。测量FAZ面积、中心凹点厚度、中心1 mm亚区厚度、视网膜内囊肿发生率、椭圆体区破裂和视网膜内层结构紊乱（DRIL）长度。也记录了。使用回归模型探讨FAZ面积和VA之间的相关性。结果：平均年龄为62.9 ± 13.2岁。视网膜分支静脉阻塞组和视网膜中央静脉阻塞组之间的人口统计学和OCT衍生的解剖学测量结果无差异（所有P >= 0.058）;因此，将两组的数据合并到一个RVO组中进行进一步的统计学比较。单因素和多元回归分析显示，DR和RVO患者FAZ面积与VA显著相关（均P = 0.225）。结论：DR和RVO患者FAZ面积与VA显著相关，且这种关系受患者年龄的影响。在视网膜血管性疾病的自然病程及治疗过程中，FAZ面积与VA的相关性有待进一步研究。(C)2016年美国眼科学会。
Purpose: To determine if the area of the foveal avascular zone (FAZ) is correlated with visual acuity (VA) in diabetic retinopathy (DR) and retinal vein occlusion (RVO).Design: Cross-sectional study.Participants: Ninety-five eyes of 66 subjects with DR (65 eyes), branch retinal vein occlusion (19 eyes), and central retinal vein occlusion (11 eyes).Methods: Structural optical coherence tomography (OCT; Spectralis, Heidelberg Engineering) and OCT angiography (OCTA; Avanti, Optovue RTVue XR) data from a single visit were analyzed. FAZ area, point thickness of central fovea, central 1-mm subfield thickness, the occurrence of intraretinal cysts, ellipsoid zone disruption, and disorganization of retinal inner layers (DRIL) length were measured. VA was also recorded. Correlations between FAZ area and VA were explored using regression models. Main outcome measure was VA.Results: Mean age was 62.9 +/- 13.2 years. There was no difference in demographic and OCT-derived anatomic measurements between branch retinal vein occlusion and central retinal vein occlusion groups (all P >= 0.058); therefore, data from the 2 groups were pooled together to a single RVO group for further statistical comparisons. Univariate and multiple regression analysis showed that the area of the FAZ was significantly correlated with VA in DR and RVO (all P = 0.225).Conclusions: The area of the FAZ is significantly correlated with VA in DR and RVO and this relationship is modulated by patient age. Further study about FAZ area and VA correlations during the natural course of retinal vascular diseases and following treatment is warranted. (C) 2016 by the American Academy of Ophthalmology.