An MRI Hyperintense Acute Reperfusion Marker Is Related to Elevated Peripheral Monocyte Count in Acute Ischemic Stroke
An MRI Hyperintense Acute Reperfusion Marker Is Related to Elevated Peripheral Monocyte Count in Acute Ischemic Stroke
复制标题
DOI：
10.1111/jon.12462
复制
发表时间：
2018-01-01
影响因子：
2.4
通讯作者：
Latour, Lawrence L.
中科院分区：
文献类型：
--
作者：
Nadareishvili, Zurab;Luby, Marie;Latour, Lawrence L.
背景和结论在急性缺血性卒中中，磁共振成像（MRI）检测到血脑屏障（BBB）破坏作为高信号急性再灌注标志物（HARM）与基质金属蛋白酶-9（MMP-9）上调相关。尽管活化的白细胞（包括单核细胞）是MMPs的主要来源，但支持急性缺血性卒中患者白细胞活化与BBB破坏之间关系的数据有限。本研究的目的是调查急性缺血性卒中患者中，中性粒细胞、淋巴细胞和单核细胞与血脑屏障破坏（检测为HARM（+））之间的关系。
BACKGROUND AND PURPOSEBlood-brain barrier (BBB) disruption detected on magnetic resonance imaging (MRI) in acute ischemic stroke as a hyperintense acute reperfusion marker (HARM) is associated with upregulation of matrix metalloproteinase-9 (MMP-9). Although activated leukocytes, including monocytes, are the main source of MMPs, limited data exist to support relationship between leukocyte activation and BBB disruption in patients with acute ischemic stroke. The goal of this study is to investigate the relationship between neutrophils, lymphocytes, and monocytes with BBB disruption detected as HARM (+) in patients with acute ischemic stroke.METHODSWe conducted a retrospective analysis of prospectively collected data in patients who did not receive any reperfusion therapy with acute (