Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization
Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization
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DOI：
10.3390/nano9040591
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发表时间：
2019-04-01
期刊：
影响因子：
5.3
通讯作者：
Kim, Yong-Il
中科院分区：
文献类型：
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作者：
Bae, Jungin;Son, Woo-Sung;Kim, Yong-Il
牙本质过敏（DH）是最常见的临床状况之一，通常与暴露的牙本质表面有关。在这项研究中，我们确定了聚氨基胺（PAMAM）树突包覆的介孔生物活性玻璃纳米颗粒（MBN） （PAMAM@MBN）对DH治疗的有效性，研究了离子释放效应、牙本质再矿化和牙本质小管的阻塞效应。我们合成了MBN和PAMAM@MBN。在模拟体液（SBF）中浸泡后，观察离子释放效应和牙本质再矿化效应30天。同时，我们准备了30颗前磨牙，分别应用MBN和PAMAM@MBN后，观察牙髓小管闭塞的比例。结果表明PAMAM不破坏MBN的钙离子释放能力和牙本质再矿化。PAMAM@MBN对牙本质小管的封堵效果优于MBN （p < 0.05）。在牙本质小管咬合方面，由于PAMAM， MBN之间的间隙被很好地咬合。这表明PAMAM@MBN可以有效地用于牙本质小管的封闭和再矿化。
Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and PAMAM@MBN, respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The PAMAM@MBN showed a better occluding effect for dentinal tubules than that of MBN (p < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that PAMAM@MBN could be effectively used in dentinal tubule sealing and remineralization.