Therapeutic Interventions in Adult Low-Grade Gliomas.

Therapeutic Interventions in Adult Low-Grade Gliomas.
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DOI:
10.3988/jcn.2019.15.1.1
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发表时间:
2019-01
期刊:
Journal of clinical neurology (Seoul, Korea)
影响因子:
--
通讯作者:
Assi H
Assi H
中科院分区:
其他
文献类型:
--
作者:
Chammas M;Saadeh F;Maaliki M;Assi H

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由于成人低级别胶质瘤 (LGG) 具有高度浸润性,治疗这种脑癌尤其具有挑战性。尽管手术、放疗和化疗是 LGG 的主要治疗方式,但根据个体症状和治疗引起的毒性风险,针对特定患者的最佳联合治疗方案仍不清楚。这篇综述强调了标准治疗方案的能力和局限性,同时提供了有关当前临床试验的重要治疗更新,旨在实施靶向治疗,其发病率低于当前 LGG 治疗的发病率,并增强癌细胞的杀伤力,同时保持改善的生活质量。
Treating adult low-grade gliomas (LGGs) is particularly challenging due to the highly infiltrative nature of this type of brain cancer. Although surgery, radiotherapy, and chemotherapy are the mainstay treatment modalities for LGGs, the optimal combination management plan for a particular patient based on individual symptoms and the risk of treatment-induced toxicity remains unclear. This review highlights the competency and limitations of standard treatment options while providing an essential therapeutic update regarding current clinical trials aimed at implementing targeted therapies with morbidity rates lower than those for current LGG treatments and also augmenting the killing of cancerous cells while maintaining an improved quality of life.
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