Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice
Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice
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腹侧齿状回区域小白蛋白阳性中间神经元的缺陷与小鼠的抑郁样行为有关
DOI：
10.1016/j.bbi.2021.09.013
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发表时间：
2021-09-28
影响因子：
15.1
通讯作者：
Fang, Marong
中科院分区：
文献类型：
--
作者：
Chen, Shijia;Chen, Fengpei;Fang, Marong
抑郁症是一种越来越常见但极其严重的情绪障碍，人们对它的了解仍然很少，治疗也不充分。小清蛋白阳性中间神经元（PVIs）是GABA能中间神经元（GABA，g-氨基丁酸）的一个亚群，广泛分布于海马，在多种精神疾病中发挥重要作用。然而，抑郁症和海马PVIs之间的关系仍不清楚。在本研究中，进行了一系列实验来阐明潜在的关系。在这里，慢性不可预测的轻度应激（CNOMS）和脂多糖（LPS）注射诱导小鼠抑郁样行为，并导致腹侧海马（vHPC），特别是腹侧齿状回（vDG）子区的PVIs数量明显下降。在PV-ires-Cre：：Ai 14小鼠中选择性去除PVI后，我们证实了从vDG中消融PVI诱导了抑郁样行为。此外，我们发现vDG-PVIs的去除诱导的抑郁可能是神经炎症上调的原因。这些发现有助于我们更好地理解海马PVIs在抑郁症中的作用。
Depression is an increasingly common but extremely serve mood disorder that remains poorly understood and inadequately treated. Fast-spiking parvalbumin-positive interneurons (PVIs), a subpopulation of GABAergic interneurons (GABA, g-aminobutyric acid), exhibit a widespread distribution throughout the hippocampus, and has been reported to play an important role in a variety of mental disorders. However, the relationship between depression and hippocampal PVIs remains unclear. Here in this present study, a series of experiments were conducted to clarify the potential relationship. Here, chronic unpredicted mild stress (CUMS) and Lipopolysaccharide (LPS) injection were introduced to induce depression-like behavior in mice, and led to a clear decline in PVIs numbers in the ventral hippocampal (vHPC), particularly in the ventral dentate gyrus (vDG) subfield. After a selectively removal of the PVIs in PV-ires-Cre::Ai14 mice, we confirmed that ablation of PVIs from the vDG induced depression-like behavior. Furthermore, we found that the removal of vDG-PVIs induced depression likely to be accounted for upregulation of neuroinflammation. These findings facilitate us better understand the role of hippocampal PVIs in depression.