A distinct coagulopathy associated with interleukin-2 therapy.
A distinct coagulopathy associated with interleukin-2 therapy.
复制标题
一种与白细胞介素 2 治疗相关的独特凝血病。
DOI:
10.1111/j.1365-2141.1994.tb05135.x
复制
发表时间:
1994
影响因子:
6.5
通讯作者:
Wiernik,PH
中科院分区:
文献类型:
--
作者:
Oleksowicz,L;Strack,M;Dutcher,JP;Sussman,I;Caliendo,G;Sparano,J;Wiernik,PH
We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin‐2 (IL‐2). A 43% prolongation of the PTT (P<0.001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL‐2 treatment in comparison to pretreatment values. These parameters normalized within 2–3 d following IL‐2 administration. The PT, factors V. VII, VIII, fibrinogen and D‐dimer levels were unchanged with IL‐2 treatment. This pattern of coagulopathy has not previously been reported.
登录
查看更多内容
DOI:
--
发表时间:
1984
期刊:
影响因子:
--
作者:
Eric K. Johnson;D. Nurok
通讯作者:
D. Nurok
DOI:
--
发表时间:
1981
期刊:
影响因子:
--
作者:
R. Ohmacht;I. Halasz
通讯作者:
I. Halasz
DOI:
--
发表时间:
1979
期刊:
影响因子:
--
作者:
Helmut Elgass;H. Engelhardt;I. Halasz
通讯作者:
I. Halasz
影响因子:
7.4
作者:
Shelly,DC;Gluckman,JC;Novotny,MV
通讯作者:
Novotny,MV
DOI:
--
发表时间:
1980
期刊:
影响因子:
--
作者:
R. Majors
通讯作者:
R. Majors