Alterations in metabolism and gap junction expression may determine the role of astrocytes as "Good samaritans" or executioners
Alterations in metabolism and gap junction expression may determine the role of astrocytes as "Good samaritans" or executioners
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DOI：
10.1002/glia.20213
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发表时间：
2005-06-01
期刊：
影响因子：
6.2
通讯作者：
Rozental, R
中科院分区：
文献类型：
--
作者：
Farahani, R;Pina-Benabou, MH;Rozental, R
在过去的十年里，我们对星形胶质细胞及其在中枢神经系统(CNS)中的生理和病理生理作用的了解不断增长，揭示了一幅复杂的图景。越来越清楚的是，神经胶质细胞在中枢神经系统的稳态和功能中扮演着重要的角色，神经元不再被认为是唯一对电化学活动做出快速和缓慢反应的细胞类型。我们讨论了这一领域的最新进展，重点是缺氧和缺血对星形胶质细胞代谢的影响，以及星形胶质细胞中葡萄糖代谢和缝隙连接之间的功能关系。我们还讨论了星形胶质细胞缝隙连接是否在缺氧或缺血损伤期间或之后介导神经元保护或死亡的争议。(C)2005年Wiley-Liss，Inc.
Our knowledge of astroglia and their physiological and pathophysiological role(s) in the central nervous system (CNS) has grown during the past decade, revealing a complex picture. It is becoming increasingly clear that glia play a significant role in the homeostasis and function of the CNS and that neurons should no longer be considered the only cell type that responds, both rapidly and slowly, to electrochemical activity. We discuss recent advances in the field with an emphasis on the impact of hypoxia and ischemia on astrocytic metabolism and the functional relationship between glucose metabolism and gap junctions in astrocytes. We also address the controversy over whether astrocytic gap junctions mediate protection or killing of neurons during or after hypoxic or ischemic insults. (c) 2005 Wiley-Liss, Inc.