Capillary and interstitial forces during fluid absorption in the cat small intestine.
Capillary and interstitial forces during fluid absorption in the cat small intestine.
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DOI：
10.1016/0016-5085(84)90410-4
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发表时间：
1984-02
期刊：
影响因子：
29.4
通讯作者：
D. Granger;M. Perry;P. Kvietys;A. Taylor
中科院分区：
文献类型：
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作者：
D. Granger;M. Perry;P. Kvietys;A. Taylor
在猫回肠吸收和非吸收条件下，进行了系统的稳态分析的力和膜系数的跨毛细血管和淋巴液流量。在用葡萄糖（20 mM）-台氏液灌注回肠腔之前和期间，测量净透粘膜液流量、淋巴液流量、毛细血管压力、血流量、毛细血管滤过系数以及淋巴液和血浆粘附压。从测量的参数计算两种情况下的间隙流体压力。刺激粘膜液吸收导致淋巴流量增加（增加3倍）、毛细血管滤过系数增加（增加2倍）、毛细血管压力增加（增加9%）、间质液压力增加（增加2倍）和血流量增加（增加16%），而间质（淋巴）粘附压力下降（20%）。这些变化将过滤毛细血管转化为吸收毛细血管，从而允许82%的吸收液体通过毛细血管从粘膜中移除，而吸收剂移除剩余的18%。本研究的结果表明，小肠内的流体静力学和膨胀力是防止小肠净液体吸收期间间质液蓄积的主要原因。
A systematic steady-state analysis of the forces and membrane coefficients governing transcapillary and lymphatic fluid fluxes was performed in the cat ileum under absorptive and nonabsorptive conditions. Net transmucosal fluid flux, lymph flow, capillary pressure, blood flow, capillary filtration coefficient, and lymph and plasma oncotic pressures were measured before and during perfusion of the ileal lumen with a glucose (20 mM)-Tyrode's solution. Interstitial fluid pressure was calculated for the two conditions from measured parameters. Stimulation of mucosal fluid absorption resulted in an increase in lymph flow (which tripled), capillary filtration coefficient (which doubled), capillary pressure (which increased by 9%), interstitial fluid pressure (which doubled), and blood flow (which increased by 16%), whereas interstitial (lymph) oncotic pressure fell (by 20%). These changes converted filtering capillaries to absorbing capillaries, thereby allowing 82% of the absorbed fluid to be removed from the mucosal interstitium via the capillaries, while the lymphatics removed the remaining 18%. The results of this study indicate that hydrostatic and oncotic forces within the interstitium are primarily responsible for preventing interstitial fluid accumulation during periods of net fluid absorption in the small bowel.