Pathophysiological Roles of Gap Junction in Glomerular Mesangial Cells
Pathophysiological Roles of Gap Junction in Glomerular Mesangial Cells
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DOI：
10.1007/s00232-007-9023-2
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发表时间：
2007-07
影响因子：
2.4
通讯作者：
Jian Yao;Ying Zhu;T. Morioka;T. Oite;M. Kitamura
中科院分区：
文献类型：
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作者：
Jian Yao;Ying Zhu;T. Morioka;T. Oite;M. Kitamura
肾小球系膜细胞（MC）是专门的血管平滑肌细胞，在控制肾小球血流动力学中发挥着关键作用。 MC 的有趣特征之一是其间隙连接 (GJ) 异常丰富。长期以来，人们推测 GJ 可能将 MC 桥接在一起，并为系膜提供功能性合胞体的特征。不断积累的科学证据支持这一想法。据报道，GJ 关键参与重要的生理过程，如肾小球反馈和肾小球滤过。此外，GJ 还参与 MC 的许多细胞过程的控制，包括生长、分化和存活。本文总结了目前关于 GJ 在肾小球病理生理学中的作用的知识。
Glomerular mesangial cells (MCs) are specialized vascular smooth muscle cells that play a critical role in the control of glomerular hemodynamics. One of the intriguing features of MCs is their extraordinary abundance in gap junctions (GJs). It has long been speculated that GJs may bridge MCs together and provide the mesangium with the characteristics of a functional syncytium. Accumulating scientific evidence supports this idea. GJs are reported to be critically involved in important physiological processes like tubuloglomerular feedback and glomerular filtration. In addition, GJs are implicated in the control of many cellular processes of MCs, including growth, differentiation and survival. This article summarizes the current knowledge on the roles of GJs in glomerular pathophysiology.