Structural plasticity of the bilateral hippocampus in glioma patients
Structural plasticity of the bilateral hippocampus in glioma patients
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胶质瘤患者双侧海马的结构可塑性
DOI：
10.18632/aging.103212
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发表时间：
2020-06-15
期刊：
影响因子：
5.2
通讯作者：
Li, Chuzhong
中科院分区：
文献类型：
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作者：
Yuan, Taoyang;Ying, Jianyou;Li, Chuzhong
本研究旨在探讨胶质瘤患者术前海马结构的可塑性和神经元反应。99例无双侧海马受累的胶质瘤患者（低级别，n=52;高级别，n=47）和80名健康对照者，均接受3D T1图像和静息功能MRI检查。分析各组海马体积和低频波动动态幅度（dALFF）。海马体积和临床特征之间的关系进行了评估。我们观察到低级别和高级别胶质瘤的远端海马体积增加，同侧海马的反应比对侧海马更大。高级别胶质瘤双侧海马dALFF显著增加。肿瘤相关癫痫和IDH-1突变并不影响胶质瘤患者的海马体积。在高级别胶质瘤中，海马体积与年龄无显著相关性。Kaplan-Meier曲线和对数秩检验显示，与海马体积小相比，海马体积大与总生存期（OS）较短相关（p=0.007）。多变量考克斯回归分析显示，海马体积大是高级别胶质瘤患者OS不利的独立预测因素（HR=3.597，95%CI：1.160-11.153，p=0.027）。提示海马对胶质瘤的病理刺激反应具有明显的可塑性，海马对胶质瘤的反应可能与肿瘤的恶性程度有关。
This study investigates the structural plasticity and neuronal reaction of the hippocampus in glioma patient pre-surgery. Ninety-nine glioma patients without bilateral hippocampus involvement (low-grade, n=52; high-grade, n=47) and 80 healthy controls with 3D T1 images and resting-fMRI were included. Hippocampal volume and dynamic amplitude of low-frequency fluctuation (dALFF) were analyzed among groups. Relationships between hippocampal volume and clinical characteristics were assessed. We observed remote hippocampal volume increases in low- and high-grade glioma and a greater response of the ipsilateral hippocampus than the contralesional hippocampus. The bilateral hippocampal dALFF was significantly increased in high-grade glioma. Tumor-associated epilepsy and the IDH-1 mutation did not affect hippocampal volume in glioma patients. No significant relationship between hippocampal volume and age was observed in high-grade glioma. The Kaplan-Meier curve and log-rank test revealed that large hippocampal volume was associated with shorter overall survival (OS) compared with small hippocampal volume (p=0.007). Multivariate Cox regression analysis revealed that large hippocampal volume was an independent predictor of unfavorable OS (HR=3.597, 95% CI: 1.160-11.153, p=0.027) in high-grade glioma. Our findings suggest that the hippocampus has a remarkable degree of plasticity in response to pathological stimulation of glioma and that the hippocampal reaction to glioma may be related to tumor malignancy.