Low birthweight and Type 2 diabetes: A study on 11,162 Swedish twins
Low birthweight and Type 2 diabetes: A study on 11,162 Swedish twins
复制标题
DOI：
10.1093/ije/dyh117
复制
发表时间：
2004-10-01
影响因子：
7.7
通讯作者：
Lichtenstein, P
中科院分区：
文献类型：
--
作者：
Iliadou, A;Cnattingius, S;Lichtenstein, P
研究背景为调查瑞典双胞胎样本中低出生体重与糖尿病之间的关系。采用随机效应线性模型，对1906年至1958年出生的瑞典性别双胞胎进行研究，以探讨双胞胎之间和双胞胎内发生2型糖尿病的风险。2型糖尿病患者的平均出生体重增加1 kg（比值比[OR] = 2.13; P < 0.01），校正了年龄，性别，体重指数（BMI）和吸烟状况。同卵双胞胎的相应风险为2.03（P = 0.07），异卵双胞胎的相应风险为1.15（P = 0.71）。内和之间的影响的异质性的测试表明，没有显着差异之间的estimation.Conclusions的研究表明，胎儿生长减少增加2型糖尿病的风险，由于在子宫内编程的影响可能引起的宫内营养不良。但是，这并不排除存在共同遗传机制的可能性。
Background To investigate the association between low birthweight and diabetes in a population-based Swedish twin sample.Method A cohort of 11 162 same-sexed Swedish twins born between 1906 and 1958 was used in order to investigate the risk of developing Type 2 diabetes between and within twin pairs by utilizing random effects linear models.Results Between pairs there was a significant increase in risk of developing Type 2 diabetes for a 1-kg increase in their mean birthweight (odds ratio [OR] = 2.13; P < 0.01), adjusted for age, sex, body mass index (BMI), and smoking status. The corresponding risk within pair was 2.03 (P = 0.07) for monozygotic twins and 1.15 (P = 0.71) for dizygotic twins. The test of the heterogeneity of the within and between effects showed no significant difference between the estimates.Conclusions The study suggests that reduced fetal growth increase the risk of Type 2 diabetes due to an in utero programming effect possibly caused by intrauterine malnutrition. However, it does not exclude the possibility of a common genetic mechanism.