Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement
Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement
复制标题
过敏性紫癜儿童中 OX40 和可溶性 OX40 配体增加：与肾脏受累相关
DOI：
10.1111/j.1399-3038.2010.01111.x
复制
发表时间：
2011-02-01
影响因子：
4.4
通讯作者：
Zhang Xueguang
中科院分区：
文献类型：
--
作者：
Wang Qin;Wu Hongya;Zhang Xueguang
过敏性紫癜（HSP）是儿童最常见的血管炎疾病之一，其特征是皮疹、关节炎、腹痛和肾脏受累。t淋巴细胞活化被认为在血管炎中起关键作用。然而，T细胞在热休克中的调控作用仍然知之甚少。本研究研究了OX40/OX40L （CD134/CD252）共刺激通路，该通路可促进t细胞活化和延长存活。32例HSP患者和25例健康供者的结果显示，新鲜分离的HSP患者CD4(+) T细胞OX40表达高于健康个体。HSP患者血清中可溶性OX40L （sOX40L）水平也明显高于对照组。重要的是，与非肾炎患者相比，HSP肾炎患者血清CD4(+) T细胞OX40和sOX40L水平显著升高，表明OX40上调和sOX40L升高与患者的疾病活动度密切相关。由此可见，循环中的sOX40L可为CD4(+) OX40(+) t细胞活化提供过度共刺激信号，OX40/OX40L信号可能参与热休克病的发生。
Henoch-Schonlein purpura (HSP) is one of the most common types of vasculitis disorders in childhood and is characterized by a rash, arthritis, abdominal pain, and renal involvement. T-lymphocyte activation is considered to play a critical role in vasculitis. However, the regulation of the T cells in HSP remains poorly understood. In this study, OX40/OX40L (CD134/CD252) costimulatory pathway, which could promote T-cell activation and long survival, was investigated. Results from 32 HSP patients and 25 healthy donors revealed that the freshly isolated CD4(+) T cells from patients with HSP expressed higher OX40 than that of the cells from healthy individuals. The levels of soluble OX40L (sOX40L) in the sera of patients with HSP were also much higher than the controls. Importantly, significantly elevated levels of OX40 on CD4(+) T cells and sOX40L in sera were detected in patients with HSP with nephritis compared to patients without nephritis, indicating both OX40 upregulation and sOX40L increase were closely associated with disease activity of the patients. Thus, circulating sOX40L could provide excessive costimulatory signal for CD4(+) OX40(+) T-cell activation, and OX40/OX40L signal might contribute to the development of HSP disease.