Eccentric contraction-induced muscle damage in human flexor pollicis brevis is accompanied by impairment of motor nerve
Eccentric contraction-induced muscle damage in human flexor pollicis brevis is accompanied by impairment of motor nerve
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DOI：
10.1111/sms.13589
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发表时间：
2019-11-26
影响因子：
4.1
通讯作者：
Nakazato, Koichi
中科院分区：
文献类型：
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作者：
Ochi, Eisuke;Ueda, Hisashi;Nakazato, Koichi
背景离心性收缩（ECC）导致肌肉损伤。此外，我们还用大鼠和人的实验研究了ECCs对神经功能的影响。目的评价拇短屈肌（FPBM）体外循环术后运动神经传导速度（MCV）的变化。方法12名男性（年龄19.8 ± 1.7岁，身高172.4 ± 7.0 cm，体重64.0 ± 8.6 kg）在非优势手的FPBM上使用扭矩测力计进行最大100次ECC。优势手是控制（CON）。在ECC前、ECC后即刻和ECC后1、2和5天评估最大自主收缩（MVC）、运动范围（ROM）、DOMS和MCV。MCV计算为刺激的距离除以产生的波形的波幅。通过双因素方差分析对数值进行统计学分析，并将显著性水平设定为P。ECC后即刻（-32.9%）至5天的MVC下降显著大于CON组（P <0.05）。与ECC前和CON组相比，ECC后ROM立即下降（-21.6%）（P <0.05）。ECCs后1天和2天（5.0 cm）DOMS较ECCs前和CON增加（P <0.05）。ECCs后MCV在ECCs后即刻（-36.4%）、第1、2、5天均较CON显著延迟（P <0.05），但两组M波振幅随时间变化无显著性差异。结论FPBM的ECCs导致正中神经MCV显著延迟。
Background Eccentric contractions (ECCs) cause muscle damage. In addition, we showed that ECCs induce nerve dysfunction and damage with rats and human. Purpose We aimed to evaluate motor nerve conduction velocity (MCV) for flexor pollicis brevis muscle (FPBM) after ECCs. Methods Twelve men (years, 19.8 +/- 1.7 years; height, 172.4 +/- 7.0 cm; weight, 64.0 +/- 8.6 kg) performed maximal 100 ECCs on their FPBM of non-dominant hands with torque dynamometer. The dominant hands were control (CON). Maximal voluntary contraction (MVC), range of motion (ROM), DOMS, and MCV were assessed before, immediately post, and 1, 2, and 5 days after ECCs. MCV was calculated as the distance by stimulation divided by the latencies of the waveforms generated. Values were statistically analyzed by two-way ANOVA, and the significance level was set at P Decreases in MVC immediately (-32.9%) to 5 days after ECCs were significantly greater (P < .05) than for the CON group. ROM showed a significant decrease immediately (-21.6%) after ECCs compared with before ECCs and CON group (P < .05). DOMS after ECCs increased at 1 and 2 days (5.0 cm) after ECCs compared with before ECCs and CON (P < .05). Also, MCV after ECCs delayed significantly from immediately (-36.4%), 1, 2, and 5 days after ECCs compared with CON (P < .05), while no significant change in M-wave amplitude was observed over time for both ECCs and CON. Conclusion The present study showed that ECCs of the FPBM cause a significant delay in MCV of median nerve.