Genomic Signatures of Specialized Metabolism in Plants
Genomic Signatures of Specialized Metabolism in Plants
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DOI：
10.1126/science.1252076
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发表时间：
2014-05-02
期刊：
影响因子：
56.9
通讯作者：
Rhee, Seung Y.
中科院分区：
文献类型：
--
作者：
Chae, Lee;Kim, Taehyong;Rhee, Seung Y.
所有植物都合成生存所需的基本代谢物(初级新陈代谢)，但不同的类群产生专门用于特定环境相互作用的不同代谢物(专门化新陈代谢)。由于初级代谢和特化代谢的进化压力不同，我们调查了16个物种在这些过程的出现和维持方面的差异，这些物种包括从藻类到被子植物的主要植物谱系。我们发现，与初级代谢对应的基因相比，编码特殊代谢功能的基因已经以不同的机制在更大程度上增殖，并显示出基因组内物理聚集和共表达的谱系特有的模式。这些特性说明了植物专门化代谢的差异进化，它们共同为发现新的专门化新陈代谢过程提供了独特的信号。
All plants synthesize basic metabolites needed for survival (primary metabolism), but different taxa produce distinct metabolites that are specialized for specific environmental interactions (specialized metabolism). Because evolutionary pressures on primary and specialized metabolism differ, we investigated differences in the emergence and maintenance of these processes across 16 species encompassing major plant lineages from algae to angiosperms. We found that, relative to their primary metabolic counterparts, genes coding for specialized metabolic functions have proliferated to a much greater degree and by different mechanisms and display lineage-specific patterns of physical clustering within the genome and coexpression. These properties illustrate the differential evolution of specialized metabolism in plants, and collectively they provide unique signatures for the potential discovery of novel specialized metabolic processes.