MASSIVE CHRONIC INTERVILLOSITIS ASSOCIATED WITH RECURRENT ABORTIONS
MASSIVE CHRONIC INTERVILLOSITIS ASSOCIATED WITH RECURRENT ABORTIONS
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DOI：
10.1016/0046-8177(95)90201-5
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发表时间：
1995-11-01
期刊：
影响因子：
3.3
通讯作者：
GENEST, DR
中科院分区：
文献类型：
--
作者：
DOSS, BJ;GREENE, MF;GENEST, DR
大规模慢性绒毛间炎（MCI）是一种不寻常的胎盘病变，与胎儿生长不良和不良妊娠结局相关；此前并未发现它与自然流产或复发性流产有关。本文报道了一位患者，她经历了 10 次自然流产，并在整个三个月的 5 次妊娠中，有 4 次出现重复性大规模慢性绒毛间炎。特征性胎盘组织学包括慢性炎症细胞和纤维蛋白对母体绒毛间隙的大量浸润，但没有相关的慢性绒毛炎；细胞浸润主要由 LCA 和 CD68 免疫反应细胞组成，具有分散的 CD45RO 阳性，与单核细胞/巨噬细胞群一致，偶尔有 T 淋巴细胞。在两次妊娠中记录到母体血清甲胎蛋白升高。这些发现支持了这种不寻常的胎盘病变可能具有免疫学基础的概念，并表明 MCI 可能是组织病理学上可识别的复发性自然流产的原因。版权所有 (C) 1995 W.B.桑德斯公司
Massive chronic intervillositis (MCI) is an unusual placental lesion associated with poor fetal growth and adverse pregnancy outcome; it has not previously been associated with spontaneous abortion or recurrent pregnancy loss. This article reports a patient who had 10 spontaneous abortions with repetitious massive chronic intervillositis documented in four of five gestations spanning all three trimesters. Characteristic placental histology included massive infiltration of the maternal intervillous space by chronic inflammatory cells and fibrin, without associated chronic villitis; the cellular infiltrate was composed predominantly of LCA and CD68 immunoreactive cells with scattered CD45RO positivity, consistent with a monocyte/macrophage population with occasional T lymphocytes. Elevated maternal serum alphafetoprotein was documented in two pregnancies, These findings support the concept that this unusual placental lesion may have an immunologic basis, and suggest that MCI may be a histopathologically recognizable cause of recurrent spontaneous abortion. Copyright (C) 1995 by W.B. Saunders Company