Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism
Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism
复制标题
DOI：
10.1016/j.neuroimage.2011.02.067
复制
发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Baron-Cohen, Simon
中科院分区：
文献类型：
--
作者：
Lombardo, Michael V.;Chakrabarti, Bhismadev;Baron-Cohen, Simon
在过去的25年里，“心智失明”(代表精神状态的缺陷)一直是自闭症谱系疾病(ASC)标志性社交沟通困难背后的主要解释之一。然而，强调导致心智失明的神经系统及其与社会障碍变异的关系仍然难以捉摸。在这项研究中，我们证明了导致ASC意识失明的神经系统之一是右颞顶交界处(RTPJ)，它与社会损伤的关系。29名患有ASC的成年男性和33名年龄和智商匹配的对照组接受了fMRI扫描，同时对自己或另一个人进行反思或身体判断。对脑化回路中感兴趣的区域进行了检查，以了解关于自我和他人的脑化过程中组间激活的差异，以及与社会症状严重程度的相关性。RTPJ是ASC中唯一非典型反应的精神化区。在控件中。与肉体判断相比，rTPJ选择性地对意念化反应更强。这种对意念化的选择性在ASC中并不明显，并且在自我和他人之间都是普遍的。RTPJ对精神化的选择性也与ASC中的互惠社会损害程度有关。这些结果支持rTPJ是ASC意识盲背后的一个重要神经系统的观点。理解rTPJ与负责社会认知的其他组成部分过程的其他神经系统一起的贡献，将有助于充分解释自闭症的标志性社交沟通困难。(C)2011 Elsevier Inc.保留所有权利。
Over the last 25 years, "mindblindness" (deficits in representing mental states) has been one of the primary explanations behind the hallmark social-communication difficulties in autism spectrum conditions (ASC). However, highlighting neural systems responsible for mindblindness and their relation to variation in social impairments has remained elusive. In this study we show that one of the neural systems responsible for mindblindness in ASC and its relation to social impairments is the right temporo-parietal junction (RTPJ). Twenty-nine adult males with ASC and 33 age and IQ-matched Controls were scanned with fMRI while making reflective mentalizing or physical judgments about themselves or another person. Regions of interest within mentalizing circuitry were examined for between-group differences in activation during mentalizing about self and other and correlations with social symptom severity. RTPJ was the only mentalizing region that responded atypically in ASC. In Controls. RTPJ was selectively more responsive to mentalizing than physical judgments. This selectivity for mentalizing was not apparent in ASC and generalized across both self and other. Selectivity of RTPJ for mentalizing was also associated wills the degree of reciprocal social impairment in ASC. These results lend support to the idea that RTPJ is one important neural system behind mindblindness in ASC. Understanding the contribution of RTPJ in conjunction with other neural systems responsible for other component processes involved in social cognition will be illuminating in fully explaining the hallmark social-communication difficulties of autism. (C) 2011 Elsevier Inc. All rights reserved.