Intestinal lymphoid tissues: Is variety an asset or a liability?
Intestinal lymphoid tissues: Is variety an asset or a liability?
复制标题
DOI：
10.1097/mog.0b013e3282f4906d
复制
发表时间：
2008-03-01
影响因子：
2.5
通讯作者：
Newberry, Rodney D.
中科院分区：
文献类型：
--
作者：
Newberry, Rodney D.
综述的目的随着我们对淋巴组织发育的认识的进步，我们对肠粘膜中淋巴组织结构的多样性有了新的认识。这些知识已经转化为对粘膜淋巴组织功能的更严格的分析，并可能导致操纵这些结构的发展作为一种治疗方式。本文综述了近年来对这些结构的种类、形成和功能的研究进展。最近发现肠黏膜和粘膜下层包含三种类型的淋巴组织，从发育决定的Peyer's斑块到炎性衍生的三级淋巴组织。中间是一种独特的淋巴组织，孤立的淋巴滤泡，它具有佩耶氏斑和三级淋巴组织的特性。在健康的肠道中，Peyer's斑块和分离的淋巴滤泡产生保护性和稳态免疫反应。在慢性炎症期间，诱导性较强的淋巴组织，孤立淋巴滤泡和三级淋巴组织的功能尚不清楚，但可能包括传播不适当反应和易患恶性肿瘤的不祥作用。了解淋巴组织的多样性、它们的功能以及它们是如何发育的，可能为操纵这些结构以优化粘膜疫苗和治疗肠道炎症性疾病提供策略。
Purpose of reviewAdvances in our understanding of lymphoid tissue development has led to an appreciation of the variety of these structures in the intestinal mucosa. This knowledge has translated into more critical analysis of the function of mucosal lymphoid tissues and may lead to manipulation of development of these structures as a therapeutic modality. This review summarizes recent progress in understanding the variety, formation, and function of these structures.Recent findingsThe intestinal mucosa and submucosa contain three types of lymphoid tissues ranging from the developmentally determined Peyer's patches to the inflammatory derived tertiary lymphoid tissues. Intermediate to these is a unique lymphoid tissue, isolated lymphoid follicles, which shares properties of both Peyer's patches and tertiary lymphoid tissues. In the healthy intestine, Peyer's patches and isolated lymphoid follicles generate protective and homeostatic immune responses. During chronic inflammation, the function of the more inducible lymphoid tissues, isolated lymphoid follicles and tertiary lymphoid tissues, is unclear, but may include an ominous role propagating inappropriate responses and predisposing to malignancy.SummaryUnderstanding the variety of lymphoid tissues, how they function, and how they develop may offer strategies to manipulate these structures to optimize mucosal vaccines and treat intestinal inflammatory diseases.