Malaria: immune evasion by parasites
Malaria: immune evasion by parasites
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DOI：
10.1016/j.biocel.2004.10.009
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发表时间：
2005-04-01
影响因子：
4
通讯作者：
Himeno, K
中科院分区：
文献类型：
--
作者：
Hisaeda, H;Yasutomo, K;Himeno, K
疟疾是全世界最具生命威胁的传染病之一。尽管高度反复暴露，对自然感染的特异性免疫是缓慢获得的，即使在流行地区也很少持续很长时间。疟疾寄生虫已经进化成获得不同的免疫逃避机制，这些机制引起免疫反应不佳，并允许感染以前接触过的人。疟疾寄生虫的精明模式也阻碍了有效疫苗的开发。此外，这些机制中的一些机制对于疟疾的发病是必不可少的。本文首先概述了疟疾保护性免疫的研究概况，然后综述了疟疾寄生虫逃避宿主免疫的策略，包括抗原多样性/多态、抗原变异和完全免疫抑制。最后，讨论了基于对宿主-寄生虫关系积累的洞察力来控制疟疾的试验。(C)2004爱思唯尔有限公司。保留所有权利。
Malaria is one of the most life-threatening infectious diseases worldwide. Specific immunity to natural infection is acquired slowly despite a high degree of repeated exposure and rarely continues for a long time even in endemic areas. Malaria parasites have evolved to acquire diverse immune evasion mechanisms that evoke poor immune responses and allow infection of individuals previously exposed. The shrewd schema of malaria parasites also hampers the development of effective vaccines. Furthermore, some of those mechanisms are essential for malaria pathogenesis. In this article, an outline of protective immunity to malaria is given, then strategies used by malaria parasites to evade host immunity, including antigen diversity/polymorphism, antigen variation and total immune suppression, are reviewed. Finally, trials to control malaria based on accumulating insights into the host-parasite relationship are discussed. (C) 2004 Elsevier Ltd. All rights reserved.